DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8545 and Nsun2

DIOPT Version :9

Sequence 1:	NP_610786.2	Gene:	CG8545 / 36365	FlyBaseID:	FBgn0033741	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_663329.3	Gene:	Nsun2 / 28114	MGIID:	107252	Length:	757	Species:	Mus musculus

Alignment Length:	661	Identity:	148/661 - (22%)
Similarity:	233/661 - (35%)	Gaps:	219/661 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 FQLP--VEGEETEKDLTLQEVQQRIKDVSLVLSDFKRYRQADRSRGE------YIDLLRRDLCLY 328
            ||.|  .||||...|                         ..|.||:      |.::::.:....
Mouse    10 FQQPPQPEGEEDASD-------------------------GGRKRGQAGWEGGYPEIVKENKLFE 49

  Fly   329 YSYNEFLMEKLMDMLPLTELMEYLEASEIARPLTIRTNTLKTRRRDLAGALINRGV----NLDPL 389
            :.|.|      :.::|..|..:::|:.....|.|:|....|:..:::...|.|:..    :|:..
Mouse    50 HYYQE------LKIVPEGEWDQFMESLREPLPATLRITGYKSHAKEILHCLKNKYFKELEDLEVD 108

  Fly   390 GKWTKVGLVVFNSQVPLGATPEYLAGH-------------------YMI----------QGASSL 425
            |:..:|       ..||...||.||.|                   :::          |.|.|:
Mouse   109 GQKVEV-------PQPLSWYPEELAWHTNLSRKILRKSPLLAKFHQFLVSETESGNISRQEAVSM 166

  Fly   426 LPVMALAPQENERILDMCSAPGGKGSHI-------ASIMKNTGVLFANDSNRDRIKAIVANFHRL 483
            :|.:.|..:.:.:|||||:|||.|.:.:       .|:....|.:.|||.:..|...:|....||
Mouse   167 IPPLLLNVEPHHKILDMCAAPGSKTTQLIEMLHADMSVPFPEGFVIANDVDNKRCYLLVHQAKRL 231

  Fly   484 G-----IVNAVVSC-------EDGTKFRNIMTGFDRVLLDAPCTGTGVVSKDPSVKTTKSEVDVQ 536
            .     :||...|.       .||   |..:..:||:|.|.||:|.|.:.|:..|....:.::..
Mouse   232 SSPCIMVVNHDASSIPRLTVDVDG---RKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSL 293

  Fly   537 RCYNLQRKLLLTAIDCTDAKSSTGGYIVYSTCSVLPEENEWVI-------DYALKKRNVKLVPTG 594
            :.:.||.::.....:    :.:.||.:||||||:.|.|:|.||       :.||:..:|.....|
Mouse   294 QLHGLQLRIATRGAE----QLAEGGRMVYSTCSLNPVEDEAVIAALLEKSEGALELADVSAELPG 354

  Fly   595 LDF--GVEGF---------------------TKFRQHRFHPS---------LNLTKRYYPHTHNM 627
            |.:  ||..:                     |:.|...|.|:         |....|..||..|.
Mouse   355 LKWMPGVSQWKVMTRDGQWFADWHEVPQGRHTQIRPTMFPPTDLEKLQAMHLERCLRILPHHQNT 419

  Fly   628 DGFYVAKLKKFSNTIPITKEQQEEDEKQLDEAIEADATTEAAAESEEVEEEVASKEKGPRKLLGK 692
            .||:||.|.| ...:|..|.|.:...|            .|.|....|...||:.|
Mouse   420 GGFFVAVLVK-KAPMPWNKRQPKVQNK------------SAEAREPRVSSHVAATE--------- 462

  Fly   693 RAGKPS-FTEIEQEL----------KKKKREESKTKYVAKVFEQPVKKPK------------PE- 733
              |.|| .:|:|.::          ...:..||..|........|.||.|            ||
Mouse   463 --GNPSDQSELESQMITGAGDSETAHNTENTESNEKKDGVCGPPPSKKMKLFGFKEDPFVFIPED 525

  Fly   734 KPAEKKNEKSQAPDKQ-------TNSSESPSKSAPKQKQ--------------TNGKTTVSNSDA 777
            .|.....||..|.|..       |.::|.      |::|              .:.|..|.|:..
Mouse   526 DPLFPPIEKFYALDPSFPRMNLLTRTTEG------KKRQLYMVSKELRNVLLNNSEKMKVINTGI 584

  Fly   778 KSFNKKNKGSQ 788
            |.:.:.|.|.:
Mouse   585 KVWCRNNSGEE 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8545	NP_610786.2	Methyltr_RsmF_N	333..424	CDD:293730	22/123 (18%)
		nop2p	363..637	CDD:188051	89/364 (24%)
		Nol1_Nop2_Fmu	428..636	CDD:279522	70/265 (26%)
Nsun2	NP_663329.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		11/49 (22%)
		RsmB	28..430	CDD:223222	100/422 (24%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01023	184..190		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..504		17/90 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	716..757
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810