DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8545 and SPBP8B7.20c

DIOPT Version :9

Sequence 1:	NP_610786.2	Gene:	CG8545 / 36365	FlyBaseID:	FBgn0033741	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_596527.1	Gene:	SPBP8B7.20c / 2541274	PomBaseID:	SPBP8B7.20c	Length:	608	Species:	Schizosaccharomyces pombe

Alignment Length:	725	Identity:	316/725 - (43%)
Similarity:	417/725 - (57%)	Gaps:	149/725 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GRKAR-KQGPPVFRKQSFAPMEEEDKKLSHRQKQRFVKREQKKVVQKAKLQEKRAKGKLPQPAKR 79
            |||.: |||.|        |..||:...||            ||.:.||              ||
pombe     2 GRKQKSKQGIP--------PTLEENHNSSH------------KVTENAK--------------KR 32

  Fly    80 KTAYNSDSDPEDNEEEPQVASSDEEVPQLVPAPKGQKATAPKGFTDDNDAWLKPKKQQKQPETES 144
            |          .::|:||                                  ..:|:|...|.:|
pombe    33 K----------HSKEKPQ----------------------------------NSRKRQLAEEKKS 53

  Fly   145 EEEEEEDEESEEDSEDELGEECEEEEEGDDEEGLESDDDTAQVGKLADLSDDDDANSDDDFDISG 209
             ..|..|.|:|:|..|     .:|.||.:....||.|::..   ..||...||:|.     :..|
pombe    54 -LFENSDSENEKDLID-----ADEFEEAETLSDLEHDEEPQ---TFADEFIDDEAK-----ECEG 104

  Fly   210 EEDGAQADSDEEED-----EDDDDDDDDDDDDKLPIERANKKLKKREA-EEAQLADDEMLETV-- 266
            ||:.:..|||||.:     .||..|::|       :|.||.:...|:. |||:|.:.|..|.:
pombe   105 EEEDSVFDSDEEHEVKPMFSDDSGDEED-------LELANMEAMSRKLDEEAELEEKEAEEELHT 162

  Fly   267 -----------------DKQDVFQLPVEGEETEKDLTLQEVQQRIKDVSLVLSDFKRYRQADRSR 314
                             |.|.:..||.:         |.::|.||:::..||:|||...:..|:|
pombe   163 NIHPEAPTVLPPIDGFTDSQPISTLPQD---------LSQIQLRIQEIVRVLNDFKNLCEPGRNR 218

  Fly   315 GEYIDLLRRDLCLYYSYNEFLMEKLMDMLPLTELMEYLEASEIARPLTIRTNTLKTRRRDLAGAL 379
            .||:|.|..|:|.||.|:.||.|||.::..::|.:|:.||:|:.||:|||||||||:||:||.||
pombe   219 SEYVDQLLNDICAYYGYSRFLAEKLFELFSVSEAVEFFEANEMPRPVTIRTNTLKTQRRELAQAL 283

  Fly   380 INRGVNLDPLGKWTKVGLVVFNSQVPLGATPEYLAGHYMIQGASSLLPVMALAPQENERILDMCS 444
            |||||||:|:|||:||||.||.||||:|||||||||||::|.|||.|||||||||.|||||||.|
pombe   284 INRGVNLEPIGKWSKVGLQVFESQVPIGATPEYLAGHYILQAASSFLPVMALAPQPNERILDMSS 348

  Fly   445 APGGKGSHIASIMKNTGVLFANDSNRDRIKAIVANFHRLGIVNAVVSCEDGTKFRN-IMTGFDRV 508
            |||||.:::|::.||||::||||||:.|.||:.||.||||:.||:|...||.||.| ::.|||||
pombe   349 APGGKVTYVAALQKNTGIIFANDSNKARTKALSANIHRLGVRNAIVCNYDGRKFPNEVIGGFDRV 413

  Fly   509 LLDAPCTGTGVVSKDPSVKTTKSEVDVQRCYNLQRKLLLTAIDCTDAKSSTGGYIVYSTCSVLPE 573
            ||||||:||||:.||.||||.|||.|.....:|||:|||:|||..:|.|.|||:|||||||:..:
pombe   414 LLDAPCSGTGVIYKDQSVKTNKSERDFDTLSHLQRQLLLSAIDSVNADSKTGGFIVYSTCSITVD 478

  Fly   574 ENEWVIDYALKKR-NVKLVPTGLDFGVEGFTKFRQHRFHPSLNLTKRYYPHTHNMDGFYVAKLKK 637
            |:|.||.|||||| |||||.|||:||.||||:||:.||||||.||:|||||.||:|||:||||||
pombe   479 EDEAVIQYALKKRPNVKLVSTGLEFGREGFTRFREKRFHPSLKLTRRYYPHVHNIDGFFVAKLKK 543

  Fly   638 FSNTIP-ITKEQQEEDEKQLDEAIEADAT-TEAAAESEEVEEEVASKEKGPRKLLGKRAGKPSFT 700
            .|:.|| :......:|....|..||.::| .:....::|.::|:.  |:..||.|..:..|
pombe   544 ISDKIPTVNVADDMKDGTNNDVEIEKNSTEIDNITFNDEADKEII--EQNRRKWLKSKGYK---- 602

  Fly   701 EIEQELKKKK 710
                 :.|||
pombe   603 -----VAKKK 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8545	NP_610786.2	Methyltr_RsmF_N	333..424	CDD:293730	61/90 (68%)
		nop2p	363..637	CDD:188051	194/275 (71%)
		Nol1_Nop2_Fmu	428..636	CDD:279522	141/209 (67%)
SPBP8B7.20c	NP_596527.1	Methyltr_RsmF_N	250..328	CDD:293730	56/77 (73%)
		nop2p	267..543	CDD:188051	194/275 (71%)
		Nol1_Nop2_Fmu	332..542	CDD:279522	141/209 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	285	1.000	Domainoid score	I292
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I231
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003697
OrthoInspector	1	1.000	-	-		oto101296
orthoMCL	1	0.900	-	-		OOG6_100487
Panther	1	1.100	-	-	LDO	PTHR22807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R829
SonicParanoid	1	1.000	-	-		X2562
TreeFam	1	0.960	-	-
	12	11.850