DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8545 and Nop2

DIOPT Version :9

Sequence 1:	NP_610786.2	Gene:	CG8545 / 36365	FlyBaseID:	FBgn0033741	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_620086.2	Gene:	Nop2 / 110109	MGIID:	107891	Length:	794	Species:	Mus musculus

Alignment Length:	918	Identity:	370/918 - (40%)
Similarity:	515/918 - (56%)	Gaps:	194/918 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRKAEYSEKPKKGPGRKARKQGPPVFRKQSFAPM--EEEDKKLSHRQKQRFVKREQKKVVQKAK 63
            ||||.:.::|.|:|||||||||.........|.|.  :|..|:||.|.::|..||....|
Mouse     1 MGRKLDPTKKEKRGPGRKARKQKGAETELVRFLPAAGDENSKRLSSRARKRAAKRRAGSV----- 60

  Fly    64 LQEKRAKGKLPQPAKRKTAYNSDSDPEDNEEEPQVASSDEEVPQLVPAPKGQKATAPKGFTDDND 128
                    .:|:|.|                .|.:.:...|:.:.....:|:|..||
Mouse    61 --------DVPKPNK----------------SPGIKTLPGELSKGAVQARGKKRPAP-------- 93

  Fly   129 AWLKPKKQQKQPETESEEEEEEDEESEEDSEDELGEECEEEEEGDDEEGLESDDDTAQVGKLADL 193
                                                  .:..:||:||....||...|    .||
Mouse    94 --------------------------------------IQNSDGDEEEDSGEDDVVTQ----GDL 116

  Fly   194 --SDDDDANSDDDFDISGEEDGAQADSDEEEDE----------------------DDDDDDDDDD 234
              |:|.|.:..||:       ||.::|::||::                      :::|.|:|:|
Mouse   117 WGSEDSDEDMVDDY-------GAASNSEDEEEKLLPIERAALKQKAQDATAGVLWNEEDTDEDED 174

  Fly   235 DDKLPIERANKKLKKREAEEAQLADDEMLETVDKQDVFQLPVEGEETEKD---LTLQEVQQRIKD 296
            ||.:..|...:|..|        |:.::...|:.::.|.||..| ||::|   ..||.|.:||:|
Mouse   175 DDGVSPESHPRKDDK--------AEGDLQINVEDEEAFVLPPAG-ETDQDGQAPDLQRVHKRIQD 230

  Fly   297 VSLVLSDFKRYRQADRSRGEYIDLLRRDLCLYYSYNEFLMEKLMDMLPLTELMEYLEASEIARPL 361
            :..||.||...|:..|||.||:..|::||..||||.:||:.|||::.||:||:|:|||:|:.||:
Mouse   231 IVGVLRDFGAQREEGRSRAEYLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPI 295

  Fly   362 TIRTNTLKTRRRDLAGALINRGVNLDPLGKWTKVGLVVFNSQVPLGATPEYLAGHYMIQGASSLL 426
            |:|||||||||||||.|||||||||||||||:|.||||::|.||:||||||||||||:|||||:|
Mouse   296 TLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKSGLVVYDSSVPIGATPEYLAGHYMLQGASSML 360

  Fly   427 PVMALAPQENERILDMCSAPGGKGSHIASIMKNTGVLFANDSNRDRIKAIVANFHRLGIVNAVVS 491
            |||||||||:|||||||.|||||.|:||.:||||||:.|||:|.||:|::|.|.||||:.|.::|
Mouse   361 PVMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIIS 425

  Fly   492 CEDGTKFRNIMTGFDRVLLDAPCTGTGVVSKDPSVKTTKSEVDVQRCYNLQRKLLLTAIDCTDAK 556
            ..||.:|..::.|||||||||||:||||:||||:|||.|.|.|:|||.:||::|||:|||..:|.
Mouse   426 HYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDSVNAA 490

  Fly   557 SSTGGYIVYSTCSVLPEENEWVIDYALKKRNVKLVPTGLDFGVEGFTKFRQHRFHPSLNLTKRYY 621
            |.||||:||.|||:..||||||:|||||||||:|||||||||.||||:|:..||||:|..|:|:|
Mouse   491 SKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFQARRFHPTLRSTRRFY 555

  Fly   622 PHTHNMDGFYVAKLKKFSNTIPITKEQQEEDEKQLDEAIEADATTEAAAESEE--VEEEVASKEK 684
            |||||||||::||.|||||:||                 :..|...|||...|  ::::|..|
Mouse   556 PHTHNMDGFFIAKFKKFSNSIP-----------------QPHAGNSAAATPTEPDLKDQVTPK-- 601

  Fly   685 GPRKLLGKRAGKPSFTEIEQELKKKKREESKTKYVAKVFEQPVKKPKPEKPAEKKNEKSQAPDKQ 749
                  .:...:|:         ||.|...|.|      :|.:::|..:||.:|.|..::.|...
Mouse   602 ------SENGSQPT---------KKARGAVKAK------QQLLRQPHSKKPFQKLNGIAKGPGLS 645

  Fly   750 TNSSESPSKSAPKQKQTNGKTTVSNSDAKSFNKKNKGSQPKENGAGSPAKPDDNKPTTNGTNSPS 814
            |..|...::.:.:..|:.|...|::...:|...|.:|.:.|.:...:..||          ::||
Mouse   646 TEPSVPDAQVSTRPSQSAGNADVNSKRKRSEKLKQRGPKWKPSKEAAVPKP----------SAPS 700

  Fly   815 KSAIKETKTKPQPKGKQSPKGNAKLAKAPRVDIDDVPILEGKPIKKQNKLKQKSKQIGQLKKSTA 879
            :  :::::|.|.|    :|   :::..|||.. |..|.|      .:.|.|||.||  ||.:..|
Mouse   701 R--VEDSRTPPVP----TP---SEIRAAPRPK-DCAPSL------GEAKKKQKGKQ--QLAQQPA 747

  Fly   880 GANAGKKQ 887
            ...|..|:
Mouse   748 NGAAPLKE 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8545	NP_610786.2	Methyltr_RsmF_N	333..424	CDD:293730	68/90 (76%)
		nop2p	363..637	CDD:188051	197/273 (72%)
		Nol1_Nop2_Fmu	428..636	CDD:279522	142/207 (69%)
Nop2	NP_620086.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194		64/286 (22%)
		nop2p	297..571	CDD:188051	197/273 (72%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01023	377..383		4/5 (80%)
		PHA03247	<577..794	CDD:223021	55/247 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830991
Domainoid	1	1.000	316	1.000	Domainoid score	I1274
eggNOG	1	0.900	-	-		E1_COG0144
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	597	1.000	Inparanoid score	I951
Isobase	1	0.950	-	0	Normalized mean entropy	S1167
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003697
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100487
Panther	1	1.100	-	-	LDO	PTHR22807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R829
SonicParanoid	1	1.000	-	-		X2562
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.730