DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and KIRREL3

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_011541328.1 Gene:KIRREL3 / 84623 HGNCID:23204 Length:809 Species:Homo sapiens


Alignment Length:266 Identity:61/266 - (22%)
Similarity:103/266 - (38%) Gaps:63/266 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ISNCVWSTLLLAIFVQQTLAQRT------PTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLK 64
            ::|.:.||.|          .||      |.::...|..:.|:|....|.|:........::::|
Human   322 VTNALGSTNL----------SRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMK 376

  Fly    65 TDSDPVFLSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKL 129
                     .||.:|:.:.:            .|.:|.:::.|||.|.|:.|:..|.....||.|
Human   377 ---------RGSGVVLSNEK------------TLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTL 420

  Fly   130 SVRRPPVISDNSTQSVVASEGSEVQMECYASGYPTP-TITWRRENNAILPTDSATY--------- 184
            :|..||:||  |||:..|..|.:.|::|:....|.| .|.|..:.|.:....|..|         
Human   421 TVNGPPIIS--STQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEE 483

  Fly   185 -VGNTLRIKSVKKEDRGTYY-CVADNGVSKGD------------RRNINVEVEFAPVITVPRPRL 235
             |.:||.|.::.:.|..|.| |.|.|......            :....:|.|..|:..:....:
Human   484 GVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAV 548

  Fly   236 GQALQY 241
            |..:.:
Human   549 GAGVAF 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 21/94 (22%)
FR1 37..50 CDD:409353 3/12 (25%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 0/7 (0%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
FR2 60..63 CDD:409353 0/2 (0%)
CDR2 67..81 CDD:409353 3/13 (23%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 1/1 (100%)
FR3 84..115 CDD:409353 7/30 (23%)
Ig strand D 84..90 CDD:409353 0/5 (0%)
Ig strand E 94..102 CDD:409353 1/7 (14%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 2/7 (29%)
FR4 124..130 CDD:409353 2/5 (40%)
Ig strand G 124..130 CDD:409353 2/5 (40%)
Ig_3 134..208 CDD:404760 27/85 (32%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 2/3 (67%)
Ig strand F 201..206 CDD:409353 3/5 (60%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 1/15 (7%)
Ig strand C 256..260 CDD:409353
Ig strand E 286..290 CDD:409353
Ig strand F 300..305 CDD:409353
KIRREL3XP_011541328.1 Ig 58..149 CDD:299845
IG_like 60..149 CDD:214653
I-set 156..249 CDD:254352
Ig2_KIRREL3-like 171..252 CDD:143236
Ig_2 260..337 CDD:290606 6/24 (25%)
I-set 341..422 CDD:254352 22/101 (22%)
IGc2 355..406 CDD:197706 14/71 (20%)
Ig5_KIRREL3 424..521 CDD:143306 28/98 (29%)
IG_like 432..521 CDD:214653 22/88 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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