DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and KIRREL2

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens

Alignment Length:	397	Identity:	94/397 - (23%)
Similarity:	139/397 - (35%)	Gaps:	115/397 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VWSTLLL--------AIFVQQTLAQRTPTISYITQEQIKDIGGTVEFDCSVQYAKEY-------- 58
            |.|||.|        |.||.:..:|..||            |.......|:||..|.
Human   185 VESTLTLTPFSHDDGATFVCRARSQALPT------------GRDTAITLSLQYPPEVTLSASPHT 237

  Fly    59 -----NVLFL--------------KTDSDPVFLSTGSTL-VIKDSRFSLRYDPNSSTYKLQIKDI 103
                 .|:||              .....||..:.|..| |:.|:.|..  :|.|
Human   238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLT--EPVS---------- 290

  Fly   104 QETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQMECYASGYPTPTIT 168
                     |: |.:.|...:....|.|...|:: ....:.|....|.:....|...|.|.|.:|
Human   291 ---------CE-VSNAVGSANRSTALDVLFGPIL-QAKPEPVSVDVGEDASFSCAWRGNPLPRVT 344

  Fly   169 WRRENNA-ILPTDSATYVGNTLRIKSVKKEDRGTYYCVADNGVS--KGDRRNINVEVEFAPVITV 230
            |.|...| :|.:      |.|||:.||..||.|.|.|.|:.|:|  :|......:.|...||:|.
Human   345 WTRRGGAQVLGS------GATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTA 403

  Fly   231 PRPRLGQA---LQYDMDLECHIEAYP-PPAIVWTKDD--IQLANNQHYSISHFATADE---YTDS 286
                |..|   |:....|:|.:.|.| |.|:||:.|:  ::..:...:.:..|...:.   ....
Human   404 ----LHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPG 464

  Fly   287 TLRVITVEKRQYGDYV----CKATNRFGEAEARVNLFETIIPVCPPACGQAYIAGAEDVSATSFA 347
            .:.|:.:...|..|:.    |.|.||.||..|:.:|                  |..|:..|...
Human   465 LISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL------------------GRRDLLPTVRI 511

  Fly   348 LVGILAA 354
            :.|:.||
Human   512 VAGVAAA 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	21/122 (17%)
		FR1	37..50	CDD:409353	1/12 (8%)
		Ig strand A'	37..42	CDD:409353	0/4 (0%)
		Ig strand B	44..51	CDD:409353	0/6 (0%)
		CDR1	51..59	CDD:409353	4/20 (20%)
		Ig strand C	59..63	CDD:409353	1/3 (33%)
		FR2	60..63	CDD:409353	1/2 (50%)
		CDR2	67..81	CDD:409353	5/14 (36%)
		Ig strand C'	68..72	CDD:409353	2/3 (67%)
		Ig strand C'	79..81	CDD:409353	1/1 (100%)
		FR3	84..115	CDD:409353	4/30 (13%)
		Ig strand D	84..90	CDD:409353	1/5 (20%)
		Ig strand E	94..102	CDD:409353	0/7 (0%)
		Ig strand F	108..115	CDD:409353	1/6 (17%)
		CDR3	116..124	CDD:409353	2/7 (29%)
		FR4	124..130	CDD:409353	0/5 (0%)
		Ig strand G	124..130	CDD:409353	0/5 (0%)
		Ig_3	134..208	CDD:404760	24/74 (32%)
		Ig strand B	153..157	CDD:409353	0/3 (0%)
		Ig strand C	166..170	CDD:409353	1/3 (33%)
		Ig strand E	187..191	CDD:409353	2/3 (67%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	25/103 (24%)
		Ig strand C	256..260	CDD:409353	2/3 (67%)
		Ig strand E	286..290	CDD:409353	0/3 (0%)
		Ig strand F	300..305	CDD:409353	2/8 (25%)
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653
		IGc2	38..106	CDD:197706
		I-set	126..224	CDD:254352	13/50 (26%)
		Ig2_KIRREL3-like	141..223	CDD:143236	12/49 (24%)
		Cell attachment site. /evidence=ECO:0000255	149..151
		Ig	231..306	CDD:299845	15/96 (16%)
		IG_like	234..308	CDD:214653	16/95 (17%)
		Ig	312..395	CDD:299845	27/89 (30%)
		I-set	317..395	CDD:254352	26/83 (31%)
		Ig	397..501	CDD:299845	27/125 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810