DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and tyro3

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	XP_012824144.1	Gene:	tyro3 / 780188	XenbaseID:	XB-GENE-922144	Length:	906	Species:	Xenopus tropicalis

Alignment Length:	185	Identity:	42/185 - (22%)
Similarity:	77/185 - (41%)	Gaps:	23/185 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 SVVASEGSEVQMECYASGYPTPTITWRRE-------NNAILPTDSATYVGNTLRIKSVKKEDRGT 201
            ::..|:|.|.::.|...|...|.|.|.::       :...:|.|...:: :.|.:|:|::.|.|.
Frog    37 NMTVSQGHEAKLNCSLQGMEEPEIQWLKDGVPVQSADQMYIPVDEDHWI-SFLSLKNVERPDAGR 100

  Fly   202 YYCVADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQYDMDLECHIEAYPPPAIV-WTKDDIQ 265
            |:|.|::...|.....|.|.||..|..|:....|........::.|.....|.|.:: |...|..
Frog   101 YWCEAEHSGRKSVSDAIWVMVEGVPYFTLEPKDLSVTPNSPFNMTCAAVGPPEPLVIFWWVGDSP 165

  Fly   266 LANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFE 320
            |..:            |.:.|.|::..:.:|.  .:.|:|.|..|.:.:|..:.|
Frog   166 LGKS------------ESSPSVLQIPGIRERT--AFSCEAHNAKGVSSSRTAIVE 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653
		FR1	37..50	CDD:409353
		Ig strand A'	37..42	CDD:409353
		Ig strand B	44..51	CDD:409353
		CDR1	51..59	CDD:409353
		Ig strand C	59..63	CDD:409353
		FR2	60..63	CDD:409353
		CDR2	67..81	CDD:409353
		Ig strand C'	68..72	CDD:409353
		Ig strand C'	79..81	CDD:409353
		FR3	84..115	CDD:409353
		Ig strand D	84..90	CDD:409353
		Ig strand E	94..102	CDD:409353
		Ig strand F	108..115	CDD:409353
		CDR3	116..124	CDD:409353
		FR4	124..130	CDD:409353
		Ig strand G	124..130	CDD:409353
		Ig_3	134..208	CDD:404760	18/70 (26%)
		Ig strand B	153..157	CDD:409353	0/3 (0%)
		Ig strand C	166..170	CDD:409353	1/3 (33%)
		Ig strand E	187..191	CDD:409353	1/3 (33%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	17/91 (19%)
		Ig strand C	256..260	CDD:409353	0/4 (0%)
		Ig strand E	286..290	CDD:409353	2/3 (67%)
		Ig strand F	300..305	CDD:409353	1/4 (25%)
tyro3	XP_012824144.1	I-set	31..116	CDD:254352	19/79 (24%)
		IGc2	42..108	CDD:197706	17/66 (26%)
		Ig2_Tyro3_like	127..206	CDD:143226	17/92 (18%)
		IG_like	131..207	CDD:214653	17/90 (19%)
		FN3	211..328	CDD:238020
		fn3	337..416	CDD:278470
		PTKc_Tyro3	518..801	CDD:270659
		Pkinase_Tyr	528..796	CDD:285015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910