DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and DIP-epsilon

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_001137799.1 Gene:DIP-epsilon / 7354433 FlyBaseID:FBgn0259714 Length:467 Species:Drosophila melanogaster


Alignment Length:303 Identity:89/303 - (29%)
Similarity:145/303 - (47%) Gaps:28/303 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 GGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDPNSS--TYKLQIKDIQE 105
            |..|:..|||:....|.|.::..:...: |:..:.::.::.|.|:.:|.:..  |:.|.|.::||
  Fly    66 GRNVKLACSVKNLGSYKVAWMHFEQSAI-LTVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQE 129

  Fly   106 TDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQS-VVASEGSEVQMECYASGYPTPTITW 169
            .|.|.|.||:...|.......||:.|  ||.|.|..|.| ::..||..|.:.|.|.|.|.|||.|
  Fly   130 EDRGRYMCQINTVTAKTQYGFVKVVV
--PPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKW 192

  Fly   170 RREN-NAI----------LPTDSATYVGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVE 223
            :|:: |.|          |.|||       |.::.:.:...|.|.|:|.|||.....:.|.|.|:
  Fly   193 KRDDGNKIVINKTLEVHDLETDS-------LELERISRLHMGAYLCIASNGVPPSVSKRIKVSVD 250

  Fly   224 FAPVITVPRPRLGQALQYDMDLECHIEAYPPPAIVWTKD-DIQLANNQHYSISHFATADEYTDST 287
            |:|::.:|...:|..:.:::.|||.|||.|.....||:: |..:..:..|..........| .:|
  Fly   251 FSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHPSY-KAT 314

  Fly   288 LR--VITVEKRQYGDYVCKATNRFGEAEARVNLFETIIPVCPP 328
            :|  :..|:...||:|.|.|.|..|:.:..:.|:.:..|...|
  Fly   315 MRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQP 357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 24/89 (27%)
FR1 37..50 CDD:409353 2/6 (33%)
Ig strand A' 37..42 CDD:409353
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 2/7 (29%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 1/13 (8%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 12/32 (38%)
Ig strand D 84..90 CDD:409353 2/5 (40%)
Ig strand E 94..102 CDD:409353 3/9 (33%)
Ig strand F 108..115 CDD:409353 3/6 (50%)
CDR3 116..124 CDD:409353 1/7 (14%)
FR4 124..130 CDD:409353 2/5 (40%)
Ig strand G 124..130 CDD:409353 2/5 (40%)
Ig_3 134..208 CDD:404760 29/85 (34%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 2/3 (67%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 24/93 (26%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 2/5 (40%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
DIP-epsilonNP_001137799.1 IG_like 59..155 CDD:214653 24/89 (27%)
Ig 69..139 CDD:143165 19/70 (27%)
IG_like 165..249 CDD:214653 29/90 (32%)
IGc2 172..237 CDD:197706 24/71 (34%)
IG_like 267..348 CDD:214653 22/81 (27%)
Ig 270..339 CDD:299845 21/69 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45442818
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 1 1.000 - - otm40772
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR12231
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
87.850

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