DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and ntm

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	XP_021334871.1	Gene:	ntm / 678534	ZFINID:	ZDB-GENE-060421-6020	Length:	380	Species:	Danio rerio

Alignment Length:	336	Identity:	90/336 - (26%)
Similarity:	146/336 - (43%)	Gaps:	42/336 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WRPSISNCVWSTLLLAIFVQQTLAQRTPTISYITQEQIKDI----GGTVEFDCSVQYAKEYNVLF 62
            ||    .||...|.|...:...|..|:...|....:|:.:|    |.|:...||
Zfish     9 WR----RCVVMGLRLLFLLPAGLPVRSQGESQSDNKQMDNITIRQGETLFLSCS----------- 58

  Fly    63 LKTD--SDPVFLSTGSTLVIKDSRFSLRYDPNSS-------TYKLQIKDIQETDAGTYTCQVVIS 118
             :.|  :...:|:..|.|...:.::|:  ||..|       .:.::|:|:..||.|.|.|.|..|
Zfish    59 -QGDFVTHTAWLNRSSILYAGEDKWSV--DPRVSLVTLSQEEFTIKIEDVDVTDEGQYICAVQTS 120

  Fly   119 TVHKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSAT 183
            :..:.:: |.:.|:.||.|. |.::.:|.:|||.|.:.|.|:|.|.|.|.||.::.:   .||.:
Zfish   121 SRPRTTS-VHIIVQVPPKIV-NLSRDLVVNEGSNVTLMCLANGKPEPAIVWRMKSPS---DDSLS 180

  Fly   184 YVGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQYDMDLECH 248
            .....|.|..:.:...|.|.|.|.|.::. |.:.:.:.|.:||.::..|. :|..|.....|:|.
Zfish   181 SDSEVLDIPFISRYRAGVYECTAANDIAV-DTQTVELTVNYAPSVSDGRD-VGVTLGQRGVLQCE 243

  Fly   249 IEAYPPPAIVWTKDDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAE 313
            .:|.|.....|.:||.::.|    .:...........|.|....|.:..||:|.|.|.|:.|.|.
Zfish   244 ADAVPEADFEWYRDDRRIFN----GLDGIEIEAAGALSRLTFFNVSEADYGNYTCVAINKLGSAN 304

  Fly   314 ARVNLFETIIP 324
            ....|:|.|.|
Zfish   305 TSFVLYEIIEP 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	24/107 (22%)
		FR1	37..50	CDD:409353	4/16 (25%)
		Ig strand A'	37..42	CDD:409353	1/4 (25%)
		Ig strand B	44..51	CDD:409353	1/6 (17%)
		CDR1	51..59	CDD:409353	1/7 (14%)
		Ig strand C	59..63	CDD:409353	0/3 (0%)
		FR2	60..63	CDD:409353	0/2 (0%)
		CDR2	67..81	CDD:409353	3/13 (23%)
		Ig strand C'	68..72	CDD:409353	0/3 (0%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	11/37 (30%)
		Ig strand D	84..90	CDD:409353	1/5 (20%)
		Ig strand E	94..102	CDD:409353	2/14 (14%)
		Ig strand F	108..115	CDD:409353	3/6 (50%)
		CDR3	116..124	CDD:409353	1/7 (14%)
		FR4	124..130	CDD:409353	1/5 (20%)
		Ig strand G	124..130	CDD:409353	1/5 (20%)
		Ig_3	134..208	CDD:404760	25/73 (34%)
		Ig strand B	153..157	CDD:409353	1/3 (33%)
		Ig strand C	166..170	CDD:409353	1/3 (33%)
		Ig strand E	187..191	CDD:409353	1/3 (33%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	22/90 (24%)
		Ig strand C	256..260	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	2/3 (67%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
ntm	XP_021334871.1	Ig	44..132	CDD:325142	23/102 (23%)
		Ig_3	135..205	CDD:316449	25/73 (34%)
		I-set	228..309	CDD:333254	22/85 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8424
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850