DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and CEACAM1

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_001703.2	Gene:	CEACAM1 / 634	HGNCID:	1814	Length:	526	Species:	Homo sapiens

Alignment Length:	229	Identity:	57/229 - (24%)
Similarity:	85/229 - (37%)	Gaps:	40/229 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 PNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSA----EVKLSVRRPPVISDNSTQSVVASEGS 151
            ||:|   |.|:::.:.|.|.||.||:.|.:....|    .|...:.:|.:.|:||..   ..:..
Human   103 PNAS---LLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNP---VEDKD 161

  Fly   152 EVQMECYASGYPTPTITWRRENNAILPTDSATYVGN---TLRIKSVKKEDRGTYYCVADNGVSKG 213
            .|...|......|..:.|  .||..||......:.|   ||.:.||.:.|.|.|.|...|.||..
Human   162 AVAFTCEPETQDTTYLWW--INNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQNPVSAN 224

  Fly   214 DRRNINVEVEFAPVITVPRPRLGQALQY-----DMDLECHIEAYPPPAIVWTKDDIQLANNQHYS 273
            ....:.:.|.:.|    ..|.:..:..|     ::.|.|:..:.||....|..:.....:.|...
Human   225 RSDPVTLNVTYGP----DTPTISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGTFQQSTQELF 285

  Fly   274 ISHFATADEYTDSTLRVITVEKRQYGDYVCKATN 307
            |.:              |||...  |.|.|.|.|
Human   286 IPN--------------ITVNNS--GSYTCHANN 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	14/43 (33%)
		FR1	37..50	CDD:409353
		Ig strand A'	37..42	CDD:409353
		Ig strand B	44..51	CDD:409353
		CDR1	51..59	CDD:409353
		Ig strand C	59..63	CDD:409353
		FR2	60..63	CDD:409353
		CDR2	67..81	CDD:409353
		Ig strand C'	68..72	CDD:409353
		Ig strand C'	79..81	CDD:409353
		FR3	84..115	CDD:409353	9/23 (39%)
		Ig strand D	84..90	CDD:409353
		Ig strand E	94..102	CDD:409353	3/7 (43%)
		Ig strand F	108..115	CDD:409353	3/6 (50%)
		CDR3	116..124	CDD:409353	1/7 (14%)
		FR4	124..130	CDD:409353	2/9 (22%)
		Ig strand G	124..130	CDD:409353	2/9 (22%)
		Ig_3	134..208	CDD:404760	21/76 (28%)
		Ig strand B	153..157	CDD:409353	1/3 (33%)
		Ig strand C	166..170	CDD:409353	0/3 (0%)
		Ig strand E	187..191	CDD:409353	3/6 (50%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	17/86 (20%)
		Ig strand C	256..260	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	0/3 (0%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
CEACAM1	NP_001703.2	Ig_CEACAM_D1	36..140	CDD:143251	13/39 (33%)
		Required for homophilic binding. /evidence=ECO:0000250\|UniProtKB:P16573	39..142		14/41 (34%)
		Ig_CEACAM_D4	146..233	CDD:143217	24/91 (26%)
		IG_like	157..233	CDD:214653	20/77 (26%)
		Ig_2	240..318	CDD:290606	17/80 (21%)
		IG_like	244..304	CDD:214653	16/76 (21%)
		I-set	317..408	CDD:254352
		Ig	340..415	CDD:299845
		DUF4690	<419..451	CDD:292384
		Interaction with calmodulin. /evidence=ECO:0000250\|UniProtKB:P16573	450..462
		Interaction with FLNA. /evidence=ECO:0000250\|UniProtKB:P16573	452..526
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..513
		Required for interaction with PTPN11 and PTPN6 and for control of phosphorylation level. /evidence=ECO:0000250\|UniProtKB:P31809	489..526
		Essential for interaction with PTPN11 and PTPN6. /evidence=ECO:0000250\|UniProtKB:P31809	520..523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910