DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and ush2a

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_009291422.1 Gene:ush2a / 568982 ZFINID:ZDB-GENE-060503-794 Length:5243 Species:Danio rerio


Alignment Length:219 Identity:50/219 - (22%)
Similarity:83/219 - (37%) Gaps:66/219 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 SAEVKLSVRRPPVISD-------------NSTQSVVASEGSEVQMECYASGY--PTPTITWRREN 173
            |:::|:. ..|||:.:             |..|...:|.|:| |....:||:  |.|:::...| 
Zfish  1271 SSQLKVD-WEPPVLPNGIIIRYELFMQLLNELQRNASSYGTE-QRVFLSSGWLNPRPSLSSANE- 1332

  Fly   174 NAILPTDSATYVGN-----TLRIK--------------SVKKEDRGTYYCVADNGVSKGDRRNIN 219
            ||:.|.:|...|.|     |.|.:              :|.:...|....:|...||.....::.
Zfish  1333 NALTPPESTVVVSNLQPFSTYRFRVLTVNMAGSVLSDWAVGRTAEGVPEYMAPPQVSAVSSSSLR 1397

  Fly   220 VEVEFAPVITVPRPR--LGQALQYDMDLECHIE----AYPPPAIVWTKDDIQL-----ANNQHYS 273
            |..|      .||.:  .|:..:|.::|  |.|    .|.||.:.      |:     |....|:
Zfish  1398 VSWE------TPRDKDVRGEVTEYRVNL--HQEQMSNPYAPPIVT------QVLYSGSAQEHSYT 1448

  Fly   274 ISHFATADEYTDSTLRVITVEKRQ 297
            .......:||:.:    :||..||
Zfish  1449 AGGLKAYEEYSFT----VTVCNRQ 1468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 2/6 (33%)
FR1 37..50 CDD:409353
Ig strand A' 37..42 CDD:409353
Ig strand B 44..51 CDD:409353
CDR1 51..59 CDD:409353
Ig strand C 59..63 CDD:409353
FR2 60..63 CDD:409353
CDR2 67..81 CDD:409353
Ig strand C' 68..72 CDD:409353
Ig strand C' 79..81 CDD:409353
FR3 84..115 CDD:409353
Ig strand D 84..90 CDD:409353
Ig strand E 94..102 CDD:409353
Ig strand F 108..115 CDD:409353
CDR3 116..124 CDD:409353 50/219 (23%)
FR4 124..130 CDD:409353 2/5 (40%)
Ig strand G 124..130 CDD:409353 2/5 (40%)
Ig_3 134..208 CDD:404760 25/107 (23%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 0/3 (0%)
Ig strand E 187..191 CDD:409353 2/8 (25%)
Ig strand F 201..206 CDD:409353 0/4 (0%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 19/82 (23%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 0/3 (0%)
Ig strand F 300..305 CDD:409353
ush2aXP_009291422.1 Laminin_G_3 160..297 CDD:290121
Laminin_N 307..528 CDD:295486
EGF_Lam 529..577 CDD:238012
EGF_Lam 586..638 CDD:238012
Laminin_EGF 653..703 CDD:278482
Laminin_EGF 706..756 CDD:278482
EGF_Lam 759..797 CDD:214543
Laminin_EGF 808..857 CDD:278482
EGF_Lam 859..912 CDD:238012
EGF_Lam 913..963 CDD:238012
EGF_Lam 965..1014 CDD:238012
EGF_Lam 1015..1064 CDD:238012
FN3 1177..1253 CDD:238020
FN3 1264..1375 CDD:238020 25/106 (24%)
FN3 1386..1469 CDD:214495 23/101 (23%)
LamG 1537..1699 CDD:238058
LamG 1737..1890 CDD:238058
FN3 1981..2071 CDD:238020
FN3 2163..2253 CDD:238020
FN3 2258..2341 CDD:238020
FN3 2352..2443 CDD:238020
FN3 2447..2544 CDD:238020
FN3 2547..2633 CDD:238020
FN3 2635..2733 CDD:238020
FN3 2743..2807 CDD:238020
FN3 2830..2932 CDD:238020
fn3 2939..3014 CDD:278470
FN3 3032..>3099 CDD:238020
FN3 3542..3611 CDD:238020
FN3 3615..3701 CDD:238020
fn3 3718..3784 CDD:278470
FN3 3801..3887 CDD:238020
FN3 3908..3971 CDD:238020
FN3 3996..4086 CDD:238020
FN3 4186..4284 CDD:238020
fn3 4288..4366 CDD:278470
FN3 4382..4465 CDD:238020
FN3 4470..4553 CDD:238020
FN3 4555..4653 CDD:238020
FN3 4679..4753 CDD:238020
fn3 4760..4830 CDD:278470
FN3 4864..4955 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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