DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and PSG2

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_112536.2 Gene:PSG2 / 5670 HGNCID:9519 Length:335 Species:Homo sapiens


Alignment Length:384 Identity:75/384 - (19%)
Similarity:120/384 - (31%) Gaps:120/384 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PSISNCVWSTLL----------LAIFVQQTLAQRTPTIS------------------YITQE-QI 39
            |...:..|..||          |....|.|:..:.|.:|                  ||..: ||
Human     8 PCTEHIKWKGLLVTASLLNFWNLPTTAQVTIEAQPPKVSEGKDVLLLVHNLPQNLTGYIWYKGQI 72

  Fly    40 KDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQ 104
            :|:         ..|...|.|       |...:..|.....:::.:|     |:|   |.|:::.
Human    73 RDL---------YHYITSYVV-------DGQIIIYGPAYSGRETAYS-----NAS---LLIQNVT 113

  Fly   105 ETDAGTYTCQVV------ISTVHKVSAEVKLSVRRPPVISDN-----STQSVVAS---EGSEVQM 155
            ..|||:||..::      .......:..:.|...:|.:.|.|     :.::|:.:   |..:...
Human   114 REDAGSYTLHIIKRGDGTRGVTGYFTFTLYLETPKPSISSSNLNPREAMETVILTCDPETPDTSY 178

  Fly   156 ECYASGYPTPTITWR---RENNAILPTDSATYVGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRN 217
            :.:.:|...| :|.|   .|.|            .||.:..|.|...|.|.|...|..|......
Human   179 QWWMNGQSLP-MTHRFQLSETN------------RTLFLFGVTKYTAGPYECEIRNSGSASRSDP 230

  Fly   218 INVEVEFAPVITVPRP-----RLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQHYSISHF 277
            :.:.:...|.:....|     |.|..|.    |.|...:.||....||.:.....:.|:..|...
Human   231 VTLNLLHGPDLPRIHPSYTNYRSGDNLY----LSCFANSNPPAQYSWTINGKFQQSGQNLFIPQI 291

  Fly   278 ATADEYTDSTLRVITVEKRQYGDYVCKATN-RFGE-----------AEARVNLFETIIP 324
            .|                :..|.|||...| ..||           |..|:.|...:.|
Human   292 TT----------------KHSGLYVCSVRNSATGEESSTSLTVKVSASTRIGLLPLLNP 334

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 19/101 (19%)
FR1 37..50 CDD:409353 3/13 (23%)
Ig strand A' 37..42 CDD:409353 2/5 (40%)
Ig strand B 44..51 CDD:409353 0/6 (0%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 2/13 (15%)
Ig strand C' 68..72 CDD:409353 1/3 (33%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 10/30 (33%)
Ig strand D 84..90 CDD:409353 1/5 (20%)
Ig strand E 94..102 CDD:409353 3/7 (43%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 0/13 (0%)
FR4 124..130 CDD:409353 0/5 (0%)
Ig strand G 124..130 CDD:409353 0/5 (0%)
Ig_3 134..208 CDD:404760 18/84 (21%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 2/3 (67%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 22/107 (21%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 0/3 (0%)
Ig strand F 300..305 CDD:409353 3/4 (75%)
PSG2NP_112536.2 Ig_CEACAM_D1 36..138 CDD:143251 23/125 (18%)
IG_like 45..>121 CDD:214653 19/99 (19%)
Ig 148..236 CDD:299845 20/100 (20%)
Ig_2 242..320 CDD:290606 20/97 (21%)
IG_like 246..318 CDD:214653 20/91 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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