DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and robo4

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_689255.3 Gene:robo4 / 560765 ZFINID:ZDB-GENE-020809-1 Length:1134 Species:Danio rerio


Alignment Length:308 Identity:71/308 - (23%)
Similarity:123/308 - (39%) Gaps:48/308 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLK------TD-----SDPVFLSTGSTLVIKD 82
            |.|.:...:.:..:|......|..:...|..:.:|:      ||     |.|:.|..||...   
Zfish    71 PRIVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRNGQPLDTDKMDAQSQPIVLPDGSLFF--- 132

  Fly    83 SRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQSVVA 147
              ||:.......:::.....|.....|..|.:  .:::|  .|.::...|..|  ||     |..
Zfish   133 --FSVVPGRKGQSHEAVYACIAHNSIGNATSR--NASLH--IAALREDFRVQP--SD-----VEV 184

  Fly   148 SEGSEVQMECYAS-GYPTPTITWRRENNAI-LPTDSATYVGNTLRIKSVKKEDRGTYYCVADNGV 210
            :.|....:.|... |:|.|.:|||::...| ...:..|.:...|.|...:|.|.|.|.|:|.|.:
Zfish   185 AIGEMATINCSPPVGHPEPNVTWRKDGILINSSNEHYTELKGKLIIAPAQKNDSGVYSCIASNMI 249

  Fly   211 SKGDRRNINVEVEFAPVITVPRP-----RLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQ 270
            ...:.|...:.|...||: :.:|     :||::.|:    .|..:..|.|:|.|:::...|.|.:
Zfish   250 GVRESRAARLSVLAKPVL-LRKPEDVSVQLGESAQF----FCEADGDPMPSIEWSREQGPLPNGR 309

  Fly   271 HYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNL 318
             |.|:        .|.:|::..|..:..|.|.|...|:.|.:.|...|
Zfish   310 -YLIN--------PDHSLQIHYVTAQDMGRYSCTVENKLGVSVASAQL 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 18/105 (17%)
FR1 37..50 CDD:409353 1/12 (8%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 0/6 (0%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
FR2 60..63 CDD:409353 0/2 (0%)
CDR2 67..81 CDD:409353 5/13 (38%)
Ig strand C' 68..72 CDD:409353 1/3 (33%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 5/30 (17%)
Ig strand D 84..90 CDD:409353 2/5 (40%)
Ig strand E 94..102 CDD:409353 0/7 (0%)
Ig strand F 108..115 CDD:409353 2/6 (33%)
CDR3 116..124 CDD:409353 1/7 (14%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 22/75 (29%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 1/2 (50%)
Ig 227..318 CDD:416386 23/95 (24%)
Ig strand C 256..260 CDD:409353 1/3 (33%)
Ig strand E 286..290 CDD:409353 1/3 (33%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
robo4XP_689255.3 Ig1_Robo 70..169 CDD:143317 19/106 (18%)
I-set 71..168 CDD:254352 19/105 (18%)
I-set 175..261 CDD:254352 25/92 (27%)
Ig2_Robo 177..261 CDD:143201 24/90 (27%)
I-set 265..350 CDD:254352 25/98 (26%)
Ig 282..350 CDD:299845 20/80 (25%)
FN3 373..448 CDD:214495
FN3 472..560 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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