DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and lrit1a

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_001018174.2 Gene:lrit1a / 553943 ZFINID:ZDB-GENE-040924-5 Length:643 Species:Danio rerio


Alignment Length:267 Identity:59/267 - (22%)
Similarity:92/267 - (34%) Gaps:73/267 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 DPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQ 154
            ||.|      :..:..:||....||.  ..||...|.|:.:|                  |:.|.
Zfish   232 DPES------LSGVLFSD
AELRRCQG--PRVHTAVARVRSAV------------------GNNVL 270

  Fly   155 MECYASGYPTPTITWRR------ENNAILPTDSATYVGNTLRIKSVKKEDRGTYYCVADNGVSKG 213
            :.|...|.|.|.:.|||      ....:|.......|.:.|.:.:|...|.|.|.|.|.|.....
Zfish   271 LRCGTVGVPIPELAWRRADGKPLNGTVLLENSKEGIVWSILSVPAVSYRDTGKYICKATNYAGSA 335

  Fly   214 DRRNINVEVEFAPVI---TV-PRPRLGQ---------ALQYDMDLECHIEAYPPPAIVWTKDDIQ 265
            : ..|::.:..||.:   |: |:|:|..         |.|     |.||..|..|.   .|:.:.
Zfish   336 E-AVISLIINDAPKMENPTLDPKPKLKSKKPNTMVKAAYQ-----EKHIATYVSPT---PKNGLP 391

  Fly   266 LANNQHYS----------------ISHFATADEYTD---STLRVITVEKRQYGDYVCKATNRFGE 311
            |:....|:                .:..|:.|.:.:   |.|...|...:|..|.|.::....|:
Zfish   392 LSGTVSYTGPYPGMESDNAANSRMNTQTASPDGFLETNLSNLAANTSSLQQDPDRVVRSVKVIGD 456

  Fly   312 AEARVNL 318
            .:..|.|
Zfish   457 TDYTVCL 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 11/40 (28%)
FR1 37..50 CDD:409353
Ig strand A' 37..42 CDD:409353
Ig strand B 44..51 CDD:409353
CDR1 51..59 CDD:409353
Ig strand C 59..63 CDD:409353
FR2 60..63 CDD:409353
CDR2 67..81 CDD:409353
Ig strand C' 68..72 CDD:409353
Ig strand C' 79..81 CDD:409353
FR3 84..115 CDD:409353 6/24 (25%)
Ig strand D 84..90 CDD:409353 59/267 (22%)
Ig strand E 94..102 CDD:409353 0/7 (0%)
Ig strand F 108..115 CDD:409353 2/6 (33%)
CDR3 116..124 CDD:409353 2/7 (29%)
FR4 124..130 CDD:409353 2/5 (40%)
Ig strand G 124..130 CDD:409353 2/5 (40%)
Ig_3 134..208 CDD:404760 18/79 (23%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 0/3 (0%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 24/122 (20%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 2/3 (67%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
lrit1aNP_001018174.2 leucine-rich repeat 61..84 CDD:275378
LRR_8 63..119 CDD:290566
LRR_RI <77..175 CDD:238064
leucine-rich repeat 85..108 CDD:275378
LRR_8 108..167 CDD:290566
leucine-rich repeat 109..132 CDD:275378
leucine-rich repeat 133..156 CDD:275378
leucine-rich repeat 157..170 CDD:275378
LRRCT 199..243 CDD:214507 3/16 (19%)
I-set 252..343 CDD:254352 25/109 (23%)
Ig 259..333 CDD:299845 22/91 (24%)
fn3 448..515 CDD:278470 3/16 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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