DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and Ntm

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_017451354.1 Gene:Ntm / 50864 RGDID:620958 Length:367 Species:Rattus norvegicus


Alignment Length:352 Identity:90/352 - (25%)
Similarity:140/352 - (39%) Gaps:86/352 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SISNCVWS--TLLLAIFVQQTLAQRTPTISY------ITQEQIKDIGGTVEFDCS-------VQY 54
            |||   |:  |.|.|:.:.|.:..|:...::      :|..|    |.:....|:       |.:
  Rat    11 SIS---WAIFTGLAALCLFQGVPVRSGDATFPKAMDNVTVRQ----GESATLRCTIDNRVTRVAW 68

  Fly    55 AKEYNVLFLKTDS---DP--VFLSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQ 114
            .....:|:...|.   ||  |.||...|                 .|.::|:::...|.|.|||.
  Rat    69 LNRSTILYAGNDKWCLDPRVVLLSNTQT-----------------QYSIEIQNVDVYDEGPYTCS 116

  Fly   115 VVISTVHKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPT 179
            |.... |..::.|.|.|:..|.|.:.|: .:..:||:.:.:.|.|:|.|.||:|||.     :..
  Rat   117 VQTDN-HPKTSRVHLIVQVSPKIVEISS-DISINEGNNISLTCIATGRPEPTVTWRH-----ISP 174

  Fly   180 DSATYVGNT--LRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVEFAPVIT------VPRPRLG 236
            .:..:|...  |.|:.:.:|..|.|.|.|.|.|:....|.:.|.|.:.|.|:      ||..:.|
  Rat   175 KAVGFVSEDEYLEIQGITREQSGEYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVPVGQKG 239

  Fly   237 QALQYDMDLECHIEAYPPPAIVWTKDDIQL--------ANNQHYSISHFATADEYTDSTLRVITV 293
                   .|:|...|.|.....|.|||.:|        ..|:.:.            |.|....|
  Rat   240 -------TLQCEASAVPSAEFQWFKDDKRLVEGKKGVKVENRPFL------------SRLTFFNV 285

  Fly   294 EKRQYGDYVCKATNRFGEAEARVNLFE 320
            .:..||:|.|.|:|:.|...|.:.|||
  Rat   286 SEHDYGNYTCVASNKLGHTNASIMLFE 312

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 23/106 (22%)
FR1 37..50 CDD:409353 2/12 (17%)
Ig strand A' 37..42 CDD:409353 1/4 (25%)
Ig strand B 44..51 CDD:409353 0/6 (0%)
CDR1 51..59 CDD:409353 1/14 (7%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 6/18 (33%)
Ig strand C' 68..72 CDD:409353 3/5 (60%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 7/30 (23%)
Ig strand D 84..90 CDD:409353 0/5 (0%)
Ig strand E 94..102 CDD:409353 2/7 (29%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 1/7 (14%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 22/75 (29%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 2/3 (67%)
Ig strand E 187..191 CDD:409353 1/5 (20%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 1/2 (50%)
Ig 227..318 CDD:416386 25/104 (24%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 2/3 (67%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
NtmXP_017451354.1 Ig 44..132 CDD:416386 24/109 (22%)
Ig strand A' 44..49 CDD:409353 1/4 (25%)
Ig strand B 51..59 CDD:409353 1/7 (14%)
CDR1 59..63 CDD:409353 0/3 (0%)
FR2 64..70 CDD:409353 1/5 (20%)
Ig strand C 64..70 CDD:409353 1/5 (20%)
CDR2 71..83 CDD:409353 2/11 (18%)
Ig strand C' 72..76 CDD:409353 0/3 (0%)
Ig strand C' 80..83 CDD:409353 1/2 (50%)
FR3 84..118 CDD:409353 13/50 (26%)
Ig strand D 87..94 CDD:409353 3/6 (50%)
Ig strand E 97..103 CDD:409353 1/5 (20%)
Ig strand F 110..118 CDD:409353 4/7 (57%)
CDR3 119..123 CDD:409353 0/4 (0%)
Ig strand G 123..132 CDD:409353 2/8 (25%)
FR4 125..132 CDD:409353 2/6 (33%)
Ig_3 136..205 CDD:404760 22/74 (30%)
Ig strand A' 144..148 CDD:409353 0/3 (0%)
Ig strand B 151..160 CDD:409353 1/8 (13%)
Ig strand F 197..205 CDD:409353 4/7 (57%)
Ig 223..307 CDD:416386 25/102 (25%)
putative Ig strand A 223..229 CDD:409353 2/5 (40%)
Ig strand B 239..243 CDD:409353 2/10 (20%)
Ig strand C 252..256 CDD:409353 0/3 (0%)
Ig strand E 278..282 CDD:409353 2/3 (67%)
Ig strand F 292..297 CDD:409353 2/4 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166337179
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X97
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.850

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