Protein Alignment Lac and Cd274

DIOPT Version :9

• Sequence 1: NP_523713.2
• Gene: Lac / 36363
• FlyBaseID: FBgn0010238
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: NP_001178883.1
• Gene: Cd274 / 499342
• RGDID: 1566211
• Length: 290
• Species: Rattus norvegicus
• Alignment Length: 185
• Identity: 44/185 - (23%)
• Similarity: 65/185 - (35%)
• Gaps: 55/185 - (29%)

  Fly   146 VASEGSEVQMECYASGYPTP--------TITWRREN----------------------NAILPTD 180
            |...||.|.|||   .:|..        .:.|.:|:                      .|.||.|
  Rat    29 VVEYGSNVTMEC---RFPVEQKLDLLALVVYWEKEDKEVIQFVEGEEDLKPQHSSFRGRAFLPKD 90

  Fly   181 SATYVGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQYD--- 242
            ........|:|..||.:|.|.|.|:...|  ..|.:.|.::|      ..|..::.|.:..|
  Rat    91 QLLKGNAVLQITDVKLQDAGVYCCMISYG--GADYKRITLKV------NAPYRKINQRISMDPAT 147

  Fly   243 --MDLECHIEAYPPPAIVWTKDDIQLANNQHYSIS--HFATADEYTDSTLRVITV 293
              .:|.|..|.||...::||       |:.|.|:|  ...|..:..:..|.|.:|
  Rat   148 SEHELMCQAEGYPEAEVIWT-------NSDHQSLSGETTVTTSQTEEKLLNVTSV 195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653
		FR1	37..50	CDD:409353
		Ig strand A'	37..42	CDD:409353
		Ig strand B	44..51	CDD:409353
		CDR1	51..59	CDD:409353
		Ig strand C	59..63	CDD:409353
		FR2	60..63	CDD:409353
		CDR2	67..81	CDD:409353
		Ig strand C'	68..72	CDD:409353
		Ig strand C'	79..81	CDD:409353
		FR3	84..115	CDD:409353
		Ig strand D	84..90	CDD:409353
		Ig strand E	94..102	CDD:409353
		Ig strand F	108..115	CDD:409353
		CDR3	116..124	CDD:409353
		FR4	124..130	CDD:409353
		Ig strand G	124..130	CDD:409353
		Ig_3	134..208	CDD:404760	22/91 (24%)
		Ig strand B	153..157	CDD:409353	2/3 (67%)
		Ig strand C	166..170	CDD:409353	0/3 (0%)
		Ig strand E	187..191	CDD:409353	1/3 (33%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	18/74 (24%)
		Ig strand C	256..260	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	1/3 (33%)
		Ig strand F	300..305	CDD:409353
Cd274	NP_001178883.1	Ig	21..130	CDD:416386	25/105 (24%)
		FR1	21..41	CDD:409353	7/14 (50%)
		Ig strand A	21..24	CDD:409353
		Ig strand A'	26..31	CDD:409353	1/1 (100%)
		Ig strand B	33..41	CDD:409353	6/10 (60%)
		CDR1	42..53	CDD:409353	1/10 (10%)
		Ig strand C	53..59	CDD:409353	1/5 (20%)
		FR2	54..62	CDD:409353	2/7 (29%)
		CDR2	63..74	CDD:409353	0/10 (0%)
		Ig strand C'	63..68	CDD:409353	0/4 (0%)
		Ig strand C'	70..74	CDD:409353	0/3 (0%)
		FR3	75..116	CDD:409353	12/40 (30%)
		Ig strand D	84..88	CDD:409353	1/3 (33%)
		Ig strand E	96..103	CDD:409353	2/6 (33%)
		Ig strand F	107..117	CDD:409353	4/9 (44%)
		CDR3	117..121	CDD:409353	1/5 (20%)
		Ig strand G	121..130	CDD:409353	2/8 (25%)
		FR4	122..130	CDD:409353	2/7 (29%)
		Ig	138..217	CDD:416386	17/65 (26%)
		Ig strand A	138..143	CDD:409353	1/4 (25%)
		Ig strand B	150..157	CDD:409353	2/6 (33%)
		Ig strand C	162..167	CDD:409353	0/4 (0%)
		Ig strand C'	168..175	CDD:409353	3/6 (50%)
		Ig strand D	179..185	CDD:409353	1/5 (20%)
		Ig strand E	189..198	CDD:409353	3/7 (43%)
		Ig strand F	205..213	CDD:409353

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910