DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and NCAM2

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_011527877.1 Gene:NCAM2 / 4685 HGNCID:7657 Length:874 Species:Homo sapiens


Alignment Length:445 Identity:84/445 - (18%)
Similarity:151/445 - (33%) Gaps:155/445 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 STLLLAIFVQQTLAQRTPTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGS 76
            :|::|.|:.:.|..:      .::.::.|. |...|..|.|..:....|.:|..:.:        
Human   130 ATVVLEIYQKLTFRE------VVSPQEFKQ-GEDAEVVCRVSSSPAPAVSWLYHNEE-------- 179

  Fly    77 TLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVS-AEVKLSVRRPPVIS-D 139
            ...|.|:||::..:.|     |||.:|.::|.|.|.|:..:....::. .::.:.|..||.|| .
Human   180 VTTISDNRFAMLANNN-----LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMP 239

  Fly   140 NSTQSVVASEGSEVQMECYASGYPTPTITWRR------ENNA--------------ILPTDSATY 184
            ..:.:..|..|.|:...|.|||.|.|.|:|.|      ||..              |:.:|...|
Human   240 QKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPY 304

  Fly   185 V---------------------------------------------------------------- 185
            |                                                                
Human   305 VCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFT 369

  Fly   186 -----------------GNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVEFAPVITVPRP 233
                             .::|.||.||..|.|.|.|.|.:.:. |.::::.:::|:||...    
Human   370 EGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIG-GHQKSMYLDIEYAPKFI---- 429

  Fly   234 RLGQALQYD-----MDLECHIEAYPPPAIVWTKDDIQLANNQHYSISHFATADEYTDSTLRVITV 293
             ..|.:.|.     :::.|.:::.||.:|.|.:|.:.|......::..::|..:   ..|.:...
Human   430 -SNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRK---MILEIAPT 490

  Fly   294 EKRQYGDYVCKATNRFGEAEARVNLFETIIPVCPPACGQAYIAGAEDVSATSFAL 348
            ....:|.|.|.|||..|..                  .|.||....||.::.:.:
Human   491 SDNDFGRYNCTATNHIGTR------------------FQEYILALADVPSSPYGV 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 20/95 (21%)
FR1 37..50 CDD:409353 3/12 (25%)
Ig strand A' 37..42 CDD:409353 1/4 (25%)
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 0/13 (0%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 11/30 (37%)
Ig strand D 84..90 CDD:409353 2/5 (40%)
Ig strand E 94..102 CDD:409353 3/7 (43%)
Ig strand F 108..115 CDD:409353 3/6 (50%)
CDR3 116..124 CDD:409353 0/7 (0%)
FR4 124..130 CDD:409353 0/6 (0%)
Ig strand G 124..130 CDD:409353 0/6 (0%)
Ig_3 134..208 CDD:404760 32/175 (18%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 18/95 (19%)
Ig strand C 256..260 CDD:409353 1/3 (33%)
Ig strand E 286..290 CDD:409353 1/3 (33%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
NCAM2XP_011527877.1 Ig1_NCAM-2 46..137 CDD:143274 2/6 (33%)
I-set 47..136 CDD:254352 2/5 (40%)
I-set 142..218 CDD:254352 20/95 (21%)
IGc2 153..214 CDD:197706 19/74 (26%)
Ig 233..326 CDD:299845 22/92 (24%)
I-set 240..323 CDD:254352 18/82 (22%)
Ig5_NCAM-2 325..422 CDD:143278 11/97 (11%)
IG_like 333..420 CDD:214653 11/87 (13%)
IG_like 438..515 CDD:214653 18/97 (19%)
IGc2 439..507 CDD:197706 15/70 (21%)
FN3 521..613 CDD:238020 0/7 (0%)
fn3 619..703 CDD:278470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12231
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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