DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and CEACAM6

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_002474.4 Gene:CEACAM6 / 4680 HGNCID:1818 Length:344 Species:Homo sapiens


Alignment Length:275 Identity:68/275 - (24%)
Similarity:105/275 - (38%) Gaps:50/275 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 PNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSA----EVKLSVRRPPVISDNSTQSVVASEGS 151
            ||:|   |.|:::.:.|.|.||.||:.|.:....|    .|...:.:|.:.|:||..   ..:..
Human   103 PNAS---LLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHV
YPELPKPSISSNNSNP---VEDKD 161

  Fly   152 EVQMECYASGYPTPTITWRRENNAILPTDSATYVGN---TLRIKSVKKEDRGTYYCVADNGVSKG 213
            .|...|......|..:.|  .|...||......:.|   ||.:.|||:.|.|:|.|...|..|..
Human   162 AVAFTCEPEVQNTTYLWW--VNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASAN 224

  Fly   214 DRRNINVEVEFAPVITVPRP-----RLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQHYS 273
            ....:.:.|.:.|.:....|     |.|:    :::|.||..:.||....|..:.....:.|...
Human   225 RSDPVTLNVLYGPDVPTISPSKANYRPGE----NLNLSCHAASNPPAQYSWFINGTFQQSTQELF 285

  Fly   274 ISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETIIPVCPPACGQAYIAGA 338
            |.:              |||...  |.|:|:|.|      :...|..|.:.:. ...|.|.:..|
Human   286 IPN--------------ITVNNS--GSYMCQAHN------SATGLNRTTVTMI-TVSGSAPVLSA 327

  Fly   339 EDVSATSFALVGILA 353
               .||....:|:||
Human   328 ---VATVGITIGVLA 339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 14/43 (33%)
FR1 37..50 CDD:409353
Ig strand A' 37..42 CDD:409353
Ig strand B 44..51 CDD:409353
CDR1 51..59 CDD:409353
Ig strand C 59..63 CDD:409353
FR2 60..63 CDD:409353
CDR2 67..81 CDD:409353
Ig strand C' 68..72 CDD:409353
Ig strand C' 79..81 CDD:409353
FR3 84..115 CDD:409353 9/23 (39%)
Ig strand D 84..90 CDD:409353
Ig strand E 94..102 CDD:409353 3/7 (43%)
Ig strand F 108..115 CDD:409353 3/6 (50%)
CDR3 116..124 CDD:409353 1/7 (14%)
FR4 124..130 CDD:409353 2/9 (22%)
Ig strand G 124..130 CDD:409353 2/9 (22%)
Ig_3 134..208 CDD:404760 21/76 (28%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 0/3 (0%)
Ig strand E 187..191 CDD:409353 3/6 (50%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 19/95 (20%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 0/3 (0%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
CEACAM6NP_002474.4 IgV_CEACAM_D1 36..140 CDD:409430 13/39 (33%)
Ig strand B 51..55 CDD:409430
Ig strand C 64..68 CDD:409430
Ig strand E 105..109 CDD:409430 2/6 (33%)
Ig strand F 119..124 CDD:409430 2/4 (50%)
Ig strand G 133..136 CDD:409430 1/2 (50%)
IgI_hCEACAM_2_4_6_like 146..234 CDD:409402 23/92 (25%)
Ig strand B 163..167 CDD:409402 1/3 (33%)
Ig strand C 176..180 CDD:409402 1/5 (20%)
Ig strand E 198..202 CDD:409402 2/3 (67%)
Ig strand F 212..217 CDD:409402 2/4 (50%)
Ig strand G 227..230 CDD:409402 0/2 (0%)
IgC2_CEACAM5-like 243..318 CDD:409540 21/101 (21%)
Ig strand B 255..259 CDD:409540 1/3 (33%)
Ig strand C 268..272 CDD:409540 0/3 (0%)
Ig strand E 285..289 CDD:409540 1/17 (6%)
Ig strand F 296..301 CDD:409540 2/4 (50%)
Ig strand G 311..314 CDD:409540 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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