DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lac and negr1

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_009300786.1 Gene:negr1 / 445374 ZFINID:ZDB-GENE-040822-27 Length:360 Species:Danio rerio


Alignment Length:378 Identity:110/378 - (29%)
Similarity:160/378 - (42%) Gaps:61/378 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 CV---WST---LLLAIFVQQTLAQRTPTISYITQEQ--IKDIGGTVEFDCSVQYAKEYNVLFLKT 65
            ||   |.|   |.|..|:...| ....|:.|.|..:  :...|.|....|          ..|..
Zfish    11 CVSGQWLTAIILSLCCFLPSCL-PAGQTVDYTTSSESVVSRQGDTALLRC----------YLLDG 64

  Fly    66 DSDPVFLSTGSTLVIKDSRFSLRYDPNSS---------TYKLQIKDIQETDAGTYTCQVVIS-TV 120
            .|...:|:..|.:...:.::|  .||..|         .|.|||:.:..||.|.|||.:... .:
Zfish    65 ISKGAWLNRSSIIYAGNDKWS--GDPRVSIVSNVGDKHEYSLQIQKVDVTDEGVYTCSIQSERNL 127

  Fly   121 H-KVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSATY 184
            | |:   ::|.|:.||.|.|.|: .:..:|||.|.:.|.|||.|.|.|:||.    |.|:.....
Zfish   128 HPKL---IQLIVKVPPKIYDISS-DITVNEGSNVSLICAASGKPEPKISWRH----ISPSARKYE 184

  Fly   185 VGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVEFAPVITVPRP---RLGQ-ALQYDMDL 245
            .|..|.|..:.::..|.|.|.|:|.::..|.:.:.|.|.|.|.|...:.   |.|| ||     |
Zfish   185 SGEYLNITGISRDQAGDYECGAENDIASPDTKTVRVTVNFPPAIHEMKSHGVRPGQVAL-----L 244

  Fly   246 ECHIEAYPPPAIVWTKDDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFG 310
            .|...|.|.|...|.|.:.::...|...|::.::.     |.|.|..:.:.:||:|.|.|.||.|
Zfish   245 RCEAAAVPSPVFEWYKGEKRINMGQGIVINNLSSR-----SVLTVKNMTQDRYGNYTCVAVNRLG 304

  Fly   311 EAEARVNLFETIIP-----VCPPACGQAYI--AGAEDVSATSFALVGILAALL 356
            .|.|.|.|...|.|     |..||...|..  .|..:|....:.|:..|::|:
Zfish   305 TANASVPLNPIIEPTTTSAVSSPASNPAMYGSTGGAEVLLACWYLILALSSLV 357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 24/107 (22%)
FR1 37..50 CDD:409353 2/14 (14%)
Ig strand A' 37..42 CDD:409353 0/6 (0%)
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 0/7 (0%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
FR2 60..63 CDD:409353 0/2 (0%)
CDR2 67..81 CDD:409353 3/13 (23%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 14/39 (36%)
Ig strand D 84..90 CDD:409353 1/5 (20%)
Ig strand E 94..102 CDD:409353 5/16 (31%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 2/9 (22%)
FR4 124..130 CDD:409353 0/5 (0%)
Ig strand G 124..130 CDD:409353 0/5 (0%)
Ig_3 134..208 CDD:404760 27/73 (37%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 29/94 (31%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 2/3 (67%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
negr1XP_009300786.1 Ig 42..121 CDD:299845 22/90 (24%)
IG_like 44..136 CDD:214653 24/106 (23%)
I-set 140..222 CDD:254352 29/86 (34%)
IGc2 153..208 CDD:197706 22/58 (38%)
IG_like 236..312 CDD:214653 28/85 (33%)
IGc2 238..304 CDD:197706 23/75 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170576305
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H41447
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 1 1.000 - - mtm8424
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6406
SonicParanoid 1 1.000 - - X97
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
98.780

Return to query results.
Submit another query.