DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and robo2

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster


Alignment Length:320 Identity:85/320 - (26%)
Similarity:135/320 - (42%) Gaps:51/320 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 STLLLAIFVQQTLAQRTPTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGS 76
            :|..|.:.|:..|. |.|      |.|...:|.:|.|.|.:......:||:.:|       ::|.
  Fly   273 ATAFLKVHVRPFLI-RGP------QNQTAVVGSSVVFQCRIGGDPLPDVLWRRT-------ASGG 323

  Fly    77 TLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNS 141
            .:.::  |..:..|.:     |::.|:...|.|.|||: ..:.|..::|...|:|..||......
  Fly   324 NMPLR--RVHVLEDRS-----LKLDDVTLEDMGEYTCE-ADNAVGGITATGILTVHAPPKFVIRP 380

  Fly   142 TQSVVASEGSEVQMECYASGYPTPTITWRRENNA--ILP--TDSATYVGNT------LRIKSVKK 196
            ...:| ..|.||..||.|:|:|.||:.|..|.|:  :||  .|....|..|      |.|....:
  Fly   381 KNQLV-EIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTPEGRSVLSIARFAR 444

  Fly   197 EDRG-TYYCVADNGV-SKGDRRNINVEVEFAPVITVPRPRLGQA-------LQYDMDLECHIEAY 252
            ||.| ...|.|.|.| |...|..::|:.:|    .:|.|.:.|.       ::..:.|.|.....
  Fly   445 EDSGKVVTCNALNAVGSVSSRTVVSVDTQF----ELPPPIIEQGPVNQTLPVKSIVVLPCRTLGT 505

  Fly   253 PPPAIVWTKDDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEA 312
            |.|.:.|..|.|.: :.|.:...:.:.|...|.|.|:    .....|.|.|.|:||.|::
  Fly   506 PVPQVSWYLDGIPI-DVQEHERRNLSDAGALTISDLQ----RHEDEGLYTCVASNRNGKS 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 22/94 (23%)
FR1 37..50 CDD:409353 4/12 (33%)
Ig strand A' 37..42 CDD:409353 1/4 (25%)
Ig strand B 44..51 CDD:409353 2/6 (33%)
CDR1 51..59 CDD:409353 0/7 (0%)
Ig strand C 59..63 CDD:409353 2/3 (67%)
FR2 60..63 CDD:409353 2/2 (100%)
CDR2 67..81 CDD:409353 1/13 (8%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 9/30 (30%)
Ig strand D 84..90 CDD:409353 1/5 (20%)
Ig strand E 94..102 CDD:409353 1/7 (14%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 1/7 (14%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 28/84 (33%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 2/9 (22%)
Ig strand F 201..206 CDD:409353 1/4 (25%)
Ig strand G 215..218 CDD:409353 1/2 (50%)
Ig 227..318 CDD:416386 22/93 (24%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 2/3 (67%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
robo2NP_001259868.1 Ig1_Robo 90..185 CDD:143317
I-set 91..184 CDD:254352
I-set 190..279 CDD:254352 2/5 (40%)
Ig2_Robo 193..279 CDD:143201 2/5 (40%)
I-set 283..370 CDD:254352 25/108 (23%)
Ig 300..370 CDD:299845 19/84 (23%)
Ig 388..>457 CDD:299845 25/68 (37%)
I-set 479..561 CDD:254352 21/87 (24%)
Ig 496..561 CDD:143165 19/70 (27%)
FN3 588..681 CDD:238020
FN3 <817..856 CDD:238020
fn3 864..952 CDD:278470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR12231
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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