DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and dpr15

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_001287299.1	Gene:	dpr15 / 41473	FlyBaseID:	FBgn0037993	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	193	Identity:	60/193 - (31%)
Similarity:	79/193 - (40%)	Gaps:	31/193 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VQQTLAQRTPTI-SYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDS 83
            |..|..:..||| .|  |..|...|......|:|:...:..:.:|:. .|...|:...|..|.|.
  Fly   182 VATTTLKPPPTIDDY--QTIISQAGTHAYLPCNVKQLVKKPISWLRM-RDGHILTVDQTTFIADQ 243

  Fly    84 RFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPV-ISDNSTQSVVA 147
            ||...:.||...:.||||.:|..|.|||.|||  ||..|.||.|.|.:..|.. :...||:.|.|
  Fly   244 RFQSVFSPNPERWSLQIKYVQLKDEGTYECQV--STEPKASAIVHLRIVEPKTELIGESTRHVKA 306

  Fly   148 SEGSEVQMECYASGYPTPTI-----------------TWRRENNAI-----LPTDSATYVGNT 188
              ||:|::.|..|....|.:                 .||.|...|     :||.|.|....|
  Fly   307 --GSQVKLRCIISQALEPPLFINWFYNQKQIYLHNRRGWRTEIERIDLPAEVPTTSTTTTTTT 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	34/94 (36%)
		FR1	37..50	CDD:409353	2/12 (17%)
		Ig strand A'	37..42	CDD:409353	1/4 (25%)
		Ig strand B	44..51	CDD:409353	0/6 (0%)
		CDR1	51..59	CDD:409353	1/7 (14%)
		Ig strand C	59..63	CDD:409353	0/3 (0%)
		FR2	60..63	CDD:409353	0/2 (0%)
		CDR2	67..81	CDD:409353	3/13 (23%)
		Ig strand C'	68..72	CDD:409353	1/3 (33%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	14/30 (47%)
		Ig strand D	84..90	CDD:409353	2/5 (40%)
		Ig strand E	94..102	CDD:409353	3/7 (43%)
		Ig strand F	108..115	CDD:409353	4/6 (67%)
		CDR3	116..124	CDD:409353	3/7 (43%)
		FR4	124..130	CDD:409353	3/5 (60%)
		Ig strand G	124..130	CDD:409353	3/5 (60%)
		Ig_3	134..208	CDD:404760	20/78 (26%)
		Ig strand B	153..157	CDD:409353	1/3 (33%)
		Ig strand C	166..170	CDD:409353	0/20 (0%)
		Ig strand E	187..191	CDD:409353	1/2 (50%)
		Ig strand F	201..206	CDD:409353
		Ig strand G	215..218	CDD:409353
		Ig	227..318	CDD:416386
		Ig strand C	256..260	CDD:409353
		Ig strand E	286..290	CDD:409353
		Ig strand F	300..305	CDD:409353
dpr15	NP_001287299.1	IG_like	197..289	CDD:214653	34/94 (36%)
dpr15	NP_001287299.1	V-set	204..290	CDD:284989	32/88 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810