DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and dpr5

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_650080.3	Gene:	dpr5 / 41381	FlyBaseID:	FBgn0037908	Length:	336	Species:	Drosophila melanogaster

Alignment Length:	193	Identity:	55/193 - (28%)
Similarity:	88/193 - (45%)	Gaps:	28/193 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDPNSSTYKLQI 100
            :|.|..:|.|....|.|::..:..|.::: ..|...|:.|......|.||..|:..||..:.|:|
  Fly    98 REVIAALGTTARLHCRVRHLGDRAVSWIR-QRDLHILTIGIMTYTNDQRFLARHIDNSDEWVLKI 161

  Fly   101 KDIQETDAGTYTCQVVISTVHKVSAEVKLSV--RRPPVISDNSTQSVVASEGSEVQMECYASGYP 163
            ..:|:.|||.|.|||  ||..|:|...||.|  .:..::::   :.:....||::.:.|.|...|
  Fly   162 VSVQQRDAGVYECQV--STEPKISLAYKLVVVTSKAQILAN---RELFIQSGSDINLTCIAPQAP 221

  Fly   164 TP--TITWRRENNAILPTDSATYVGNTLRIKS-------------VKKEDRGTYYCVADNGVS 211
            .|  .:.|.::..  |.:|||.   ..:|::|             |:..|.|.|.|.|||..|
  Fly   222 GPYTHMLWHKDTE--LVSDSAR---GGIRVESEQQMKTSNLVISRVQHTDSGNYTCSADNSNS 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	32/94 (34%)
		FR1	37..50	CDD:409353	4/12 (33%)
		Ig strand A'	37..42	CDD:409353	2/4 (50%)
		Ig strand B	44..51	CDD:409353	1/6 (17%)
		CDR1	51..59	CDD:409353	1/7 (14%)
		Ig strand C	59..63	CDD:409353	1/3 (33%)
		FR2	60..63	CDD:409353	1/2 (50%)
		CDR2	67..81	CDD:409353	3/13 (23%)
		Ig strand C'	68..72	CDD:409353	1/3 (33%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	13/30 (43%)
		Ig strand D	84..90	CDD:409353	3/5 (60%)
		Ig strand E	94..102	CDD:409353	2/7 (29%)
		Ig strand F	108..115	CDD:409353	4/6 (67%)
		CDR3	116..124	CDD:409353	3/7 (43%)
		FR4	124..130	CDD:409353	2/5 (40%)
		Ig strand G	124..130	CDD:409353	2/5 (40%)
		Ig_3	134..208	CDD:404760	19/88 (22%)
		Ig strand B	153..157	CDD:409353	0/3 (0%)
		Ig strand C	166..170	CDD:409353	0/3 (0%)
		Ig strand E	187..191	CDD:409353	0/3 (0%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353
		Ig	227..318	CDD:416386
		Ig strand C	256..260	CDD:409353
		Ig strand E	286..290	CDD:409353
		Ig strand F	300..305	CDD:409353
dpr5	NP_650080.3	V-set	95..191	CDD:284989	32/95 (34%)
		IG_like	98..179	CDD:214653	27/83 (33%)
		IG_like	206..278	CDD:214653	21/76 (28%)
		Ig	211..278	CDD:143165	19/71 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810