DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and Ama

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_731114.2 Gene:Ama / 40831 FlyBaseID:FBgn0000071 Length:341 Species:Drosophila melanogaster


Alignment Length:318 Identity:121/318 - (38%)
Similarity:206/318 - (64%) Gaps:10/318 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LAIFVQQTLAQRTPTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLK----TDSDPVFLSTGS 76
            |||.:...|:  .|.||.|:::.:..:|.:|||:|:|:...:.:|.:.|    :|::.|.||..:
  Fly    22 LAISLDSVLS--APVISQISKDVVASVGDSVEFNCTVEEVGQLSVSWAKRPSESDTNSVVLSMRN 84

  Fly    77 TLVIKDSRFSLRY----DPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVI 137
            .|.:.|.|:::..    ...|:.|..:|::|:.:|.|.|.|||::|...||:.::.|.::.||||
  Fly    85 ILSLPDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSATEKVTKKLSLQIKTPPVI 149

  Fly   138 SDNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSATYVGNTLRIKSVKKEDRGTY 202
            ::|:.:|.:.:||..:::.|:|:|:|.|||:|.||:||::|.........||||:||.:.|||.|
  Fly   150 AENTPKSTLVTEGQNLELTCHANGFPKPTISWAREHNAVMPAGGHLLAEPTLRIRSVHRMDRGGY 214

  Fly   203 YCVADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLA 267
            ||:|.||..:.|:|.|.|||||.|.|.|.||::.|.:.:..:|||.::.||.|.:||.|:.:.|.
  Fly   215 YCIAQNGEGQPDKRLIRVEVEFRPQIAVQRPKIAQMVSHSAELECSVQGYPAPTVVWHKNGVPLQ 279

  Fly   268 NNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETIIPV 325
            :::|:.:::.|::...|.|.||:.:|.:..:|||.|.|||:.|.|:||::||:|:|||
  Fly   280 SSRHHEVANTASSSGTTTSVLRIDSVGEEDFGDYYCNATNKLGHADARLHLFQTVIPV 337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 29/102 (28%)
FR1 37..50 CDD:409353 4/12 (33%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 3/6 (50%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 4/13 (31%)
Ig strand C' 68..72 CDD:409353 1/3 (33%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 9/34 (26%)
Ig strand D 84..90 CDD:409353 1/9 (11%)
Ig strand E 94..102 CDD:409353 2/7 (29%)
Ig strand F 108..115 CDD:409353 3/6 (50%)
CDR3 116..124 CDD:409353 2/7 (29%)
FR4 124..130 CDD:409353 0/5 (0%)
Ig strand G 124..130 CDD:409353 0/5 (0%)
Ig_3 134..208 CDD:404760 34/73 (47%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 2/3 (67%)
Ig strand E 187..191 CDD:409353 2/3 (67%)
Ig strand F 201..206 CDD:409353 3/4 (75%)
Ig strand G 215..218 CDD:409353 1/2 (50%)
Ig 227..318 CDD:416386 33/90 (37%)
Ig strand C 256..260 CDD:409353 1/3 (33%)
Ig strand E 286..290 CDD:409353 2/3 (67%)
Ig strand F 300..305 CDD:409353 3/4 (75%)
AmaNP_731114.2 I-set 33..143 CDD:254352 33/109 (30%)
Ig 37..127 CDD:299845 24/89 (27%)
IG_like 154..234 CDD:214653 35/79 (44%)
IGc2 161..223 CDD:197706 30/61 (49%)
I-set 254..330 CDD:254352 28/75 (37%)
IGc2 254..322 CDD:197706 24/67 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45457239
Domainoid 1 1.000 56 1.000 Domainoid score I10976
eggNOG 1 0.900 - - E1_KOG3510
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 125 1.000 Inparanoid score I4716
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
87.800

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