DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and LSAMP

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_001305844.1 Gene:LSAMP / 4045 HGNCID:6705 Length:361 Species:Homo sapiens


Alignment Length:307 Identity:93/307 - (30%)
Similarity:138/307 - (44%) Gaps:46/307 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 ITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDP------- 91
            ||..|    |.|....|.|:          ..:|...:|:....:.....::||  ||       
Human    41 ITVRQ----GDTAILRCVVE----------DKNSKVAWLNRSGIIFAGHDKWSL--DPRVELEKR 89

  Fly    92 NSSTYKLQIKDIQETDAGTYTCQVVISTVHK-VSAEVKLSVRRPPVISDNSTQSVVASEGSEVQM 155
            :|..|.|:|:.:...|.|:|||.|  .|.|: .:::|.|.|:.||.|| |.:..|..:|||.|.:
Human    90 HSLEYSLRIQKVDVYDEGSYTCSV--QTQHEPKTSQVYLIVQVPPKIS-NISSDVTVNEGSNVTL 151

  Fly   156 ECYASGYPTPTITWRRENNAILPTDSATYVGNT--LRIKSVKKEDRGTYYCVADNGVSKGDRRNI 218
            .|.|:|.|.|.||||.    :.|| ...:.|..  |.|..:.:|..|.|.|.|.|.||..|.:.:
Human   152 VCMANGRPEPVITWRH----LTPT-GREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQV 211

  Fly   219 NVEVEFAPVITVPRPR---LGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQHYSISHFATA 280
            .|.|.:.|.||..:..   .|:    ...|:|...|.|.|...|.:||.::  |....:...:|.
Human   212 KVTVNYPPTITESKSNEATTGR----QASLKCEASAVPAPDFEWYRDDTRI--NSANGLEIKSTE 270

  Fly   281 DEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETIIPVCP 327
            .:   |:|.|..|.:..||:|.|.|.|:.|...|.:.||:.::|..|
Human   271 GQ---SSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFKRVLPTIP 314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 25/102 (25%)
FR1 37..50 CDD:409353 3/12 (25%)
Ig strand A' 37..42 CDD:409353 1/4 (25%)
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
FR2 60..63 CDD:409353 0/2 (0%)
CDR2 67..81 CDD:409353 2/13 (15%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 13/37 (35%)
Ig strand D 84..90 CDD:409353 2/5 (40%)
Ig strand E 94..102 CDD:409353 3/7 (43%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 2/8 (25%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 29/75 (39%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 2/3 (67%)
Ig strand E 187..191 CDD:409353 1/5 (20%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 25/93 (27%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 2/3 (67%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
LSAMPNP_001305844.1 Ig 38..128 CDD:386229 27/104 (26%)
Ig 132..215 CDD:386229 33/88 (38%)
Ig_3 219..294 CDD:372822 23/83 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143407
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 1 1.000 - - otm40772
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.750

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