DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lac and Dscam1

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	99/356 - (27%)
Similarity:	151/356 - (42%)	Gaps:	81/356 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IFVQQTLAQRTPTIS------YITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGS 76
            :.:.:.:...:|.:|      :||..::..: |:|...|.   |:.|.|.|.:...   |:. |:
  Fly   236 LVITEPVGSVSPQLSGNGNQEHITLTRVPKM-GSVTLMCP---AQAYPVPFFRWYK---FIE-GT 292

  Fly    77 T----LVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVI 137
            |    :|:.|     |....|.|  |.|||....|:|.|.| ||.::|...|.|..|:|..|  :
  Fly   293 TRKQAVVLND-----RVKQVSGT--LIIKDAVVEDSGKYLC-VVNNSVGGESVETVLTVTAP--L 347

  Fly   138 S---DNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSATYVGNTLRIKSVKKEDR 199
            |   |..||:|  ..|......|..:|.|..|::|.::..||..::.      .|||:||||||:
  Fly   348 SAKIDPPTQTV--DFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEP------VLRIESVKKEDK 404

  Fly   200 GTYYCVADNGVSKGDRRNINVEVE------FAPVITVPRPRLGQALQYD-------MDLECHIEA 251
            |.|.|...|     |:.:.....|      |.|      |.:.||.|.:       :.|:|....
  Fly   405 GMYQCFVRN-----DQESAEASAELKLGGRFDP------PVIRQAFQEETMEPGPSVFLKCVAGG 458

  Fly   252 YPPPAIVWTKDDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAE--A 314
            .|.|.|.|..|..::|||..|.:..:.|.:....|.|.:.:|.....|.|.|.|.::.|.||  |
  Fly   459 NPTPEISWELDGKKIANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSA 523

  Fly   315 RVNLF----------------ETIIPVCPPA 329
            ::|::                ||:|..||.|
  Fly   524 KLNVYGLPYIRQMEKKAIVAGETLIVTCPVA 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	29/98 (30%)
		FR1	37..50	CDD:409353	2/12 (17%)
		Ig strand A'	37..42	CDD:409353	0/4 (0%)
		Ig strand B	44..51	CDD:409353	2/6 (33%)
		CDR1	51..59	CDD:409353	1/7 (14%)
		Ig strand C	59..63	CDD:409353	1/3 (33%)
		FR2	60..63	CDD:409353	1/2 (50%)
		CDR2	67..81	CDD:409353	4/17 (24%)
		Ig strand C'	68..72	CDD:409353	0/3 (0%)
		Ig strand C'	79..81	CDD:409353	1/1 (100%)
		FR3	84..115	CDD:409353	11/30 (37%)
		Ig strand D	84..90	CDD:409353	1/5 (20%)
		Ig strand E	94..102	CDD:409353	3/7 (43%)
		Ig strand F	108..115	CDD:409353	3/6 (50%)
		CDR3	116..124	CDD:409353	2/7 (29%)
		FR4	124..130	CDD:409353	2/5 (40%)
		Ig strand G	124..130	CDD:409353	2/5 (40%)
		Ig_3	134..208	CDD:404760	26/76 (34%)
		Ig strand B	153..157	CDD:409353	0/3 (0%)
		Ig strand C	166..170	CDD:409353	1/3 (33%)
		Ig strand E	187..191	CDD:409353	1/3 (33%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	27/99 (27%)
		Ig strand C	256..260	CDD:409353	1/3 (33%)
		Ig strand E	286..290	CDD:409353	2/3 (67%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653	29/90 (32%)
		Ig	269..340	CDD:143165	27/85 (32%)
		IG_like	353..425	CDD:214653	26/84 (31%)
		IGc2	361..413	CDD:197706	20/57 (35%)
		I-set	433..527	CDD:254352	27/93 (29%)
		IGc2	446..517	CDD:197706	19/70 (27%)
		I-set	533..618	CDD:254352	6/22 (27%)
		IGc2	544..607	CDD:197706	6/11 (55%)
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706
		I-set	819..914	CDD:254352
		Ig	833..921	CDD:299845
		FN3	918..1011	CDD:238020
		FN3	1018..1116	CDD:238020
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810