DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and itgb4

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_005166847.1 Gene:itgb4 / 335269 ZFINID:ZDB-GENE-030131-7209 Length:1931 Species:Danio rerio


Alignment Length:313 Identity:60/313 - (19%)
Similarity:104/313 - (33%) Gaps:91/313 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 YITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSD--------PVFLSTGSTLVIKDSRFSLRY 89
            |.|....|:..|.|||..:|:.......||:|.:.|        .|.:..|...:.||       
Zfish   921 YYTVASDKEAAGAVEFPENVESVDVRVPLFIKDEDDEKKELLVQAVDVPVGIAKIGKD------- 978

  Fly    90 DPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQ 154
                   .:.|..::|..:..:|......|..:......:.::| .:|.|...|..         
Zfish   979 -------HVNITVLKEQASSVFTFLEPSYTYSRQDGVANIPIKR-QIIEDGRAQVT--------- 1026

  Fly   155 MECYASGYPTPTITWRRENNAILPTDSATY-VGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNI 218
                   |.|..:|.:.:.:.|......:| .|.|.:|..||         :.:.|...|...:.
Zfish  1027 -------YSTADLTAKDKKDYISVDGDLSYGAGETEKIVPVK---------LLELGEQDGLLEDK 1075

  Fly   219 NVEVEFAPVITVPR--PRLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQHYSISHFATAD 281
            .|: :|...:|.||  .:||:              ||       :..|.:|:....|:..|..:.
Zfish  1076 QVK-QFVMDLTNPRQSAKLGR--------------YP-------RTVITIADKPESSVMAFKKST 1118

  Fly   282 EYTDSTLRVITVEKRQYGDYVCKAT--------NRF----------GEAEARV 316
            :...:|..:.|:...:.|:....||        :||          ||||..:
Zfish  1119 QTFSTTDSLYTIPVERTGNRETPATVHWRTNKASRFDISSPLKFAPGEAEKNI 1171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 18/102 (18%)
FR1 37..50 CDD:409353 5/12 (42%)
Ig strand A' 37..42 CDD:409353 1/4 (25%)
Ig strand B 44..51 CDD:409353 4/6 (67%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 3/21 (14%)
Ig strand C' 68..72 CDD:409353 2/11 (18%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 3/30 (10%)
Ig strand D 84..90 CDD:409353 0/5 (0%)
Ig strand E 94..102 CDD:409353 1/7 (14%)
Ig strand F 108..115 CDD:409353 1/6 (17%)
CDR3 116..124 CDD:409353 1/7 (14%)
FR4 124..130 CDD:409353 0/5 (0%)
Ig strand G 124..130 CDD:409353 0/5 (0%)
Ig_3 134..208 CDD:404760 13/74 (18%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 0/4 (0%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 22/110 (20%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 1/3 (33%)
Ig strand F 300..305 CDD:409353 0/4 (0%)
itgb4XP_005166847.1 Integrin_beta 37..457 CDD:278776
EGF_2 <468..490 CDD:285248
EGF_2 545..573 CDD:285248
Integrin_B_tail 625..709 CDD:285239
Calx-beta 991..1064 CDD:295344 16/98 (16%)
FN3 1242..1326 CDD:238020
FN3 1331..1420 CDD:238020
fn3 1640..1720 CDD:278470
fn3 1751..1835 CDD:278470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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