DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and Sdk1

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_808547.3	Gene:	Sdk1 / 330222	MGIID:	2444413	Length:	2193	Species:	Mus musculus

Alignment Length:	349	Identity:	87/349 - (24%)
Similarity:	139/349 - (39%)	Gaps:	77/349 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WSTLLLAIFVQQTLAQRTPTISYITQEQIKDI---GGTVEFDCSVQYAKEYNVLFLKTDSDPVFL 72
            |:.|||.:.:.:.|||......:.|:..:..|   |..:...|..:.:......:::.||:   |
Mouse    66 WALLLLQLHLLRALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWIRNDSE---L 127

  Fly    73 STGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQV--VISTVHKVSAEVKLSVRRPP 135
            :|                 .||.||..|..:|:.|||.|.|.|  .:..:.:..:|::::.....
Mouse   128 TT-----------------YSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEIQVAYMGNF 175

  Fly   136 VISDNSTQSVVASEGSEVQM------ECYASGYPTPTITWRRENNAILPTDS-ATYVGNTLRIKS 193
            :.:|   |....|:|....:      .|     |.|.:||.||.:.|:|:.. |..:.|.|.|.:
Mouse   176 MDTD---QRKTVSQGHAALLNLLPIVSC-----PQPQVTWFREGHKIIPSSRIAITLENQLVILA 232

  Fly   194 VKKEDRGTYYCVA---DNGVSKGD-------RRNINVEVEFAPVITV-PRPRLGQALQYDMDLEC 247
            ....|.|.||..|   .||.:|..       .|:.......||:|.| |..|...|...:..|||
Mouse   233 TTASDAGAYYVQAVNEKNGENKTSPFIHLSVARDTGTHEAMAPIIVVAPGNRSVVAGSSETTLEC 297

  Fly   248 HIEAYPPP--AIVWTKDDIQLANNQH-----YSISHFATADEYTDSTLRVITVEKRQYGDYVCKA 305
            ...|.|..  ::.|.::.::|.:..|     .:|::..:||.                |.|||:|
Mouse   298 IANARPVEELSVHWKRNGVRLTSGLHSYGRRLTITNPTSADT----------------GMYVCEA 346

  Fly   306 TNRFGEAE-ARVNLFETIIPVCPP 328
            |.|....| ||...|.:||.  ||
Mouse   347 TLRGSTFEPARARAFLSIIE--PP 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	20/99 (20%)
		FR1	37..50	CDD:409353	2/15 (13%)
		Ig strand A'	37..42	CDD:409353	0/4 (0%)
		Ig strand B	44..51	CDD:409353	0/6 (0%)
		CDR1	51..59	CDD:409353	0/7 (0%)
		Ig strand C	59..63	CDD:409353	0/3 (0%)
		FR2	60..63	CDD:409353	0/2 (0%)
		CDR2	67..81	CDD:409353	3/13 (23%)
		Ig strand C'	68..72	CDD:409353	0/3 (0%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	11/30 (37%)
		Ig strand D	84..90	CDD:409353	0/5 (0%)
		Ig strand E	94..102	CDD:409353	4/7 (57%)
		Ig strand F	108..115	CDD:409353	4/6 (67%)
		CDR3	116..124	CDD:409353	0/7 (0%)
		FR4	124..130	CDD:409353	1/5 (20%)
		Ig strand G	124..130	CDD:409353	1/5 (20%)
		Ig_3	134..208	CDD:404760	22/83 (27%)
		Ig strand B	153..157	CDD:409353	0/9 (0%)
		Ig strand C	166..170	CDD:409353	1/3 (33%)
		Ig strand E	187..191	CDD:409353	2/3 (67%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	1/2 (50%)
		Ig	227..318	CDD:416386	26/99 (26%)
		Ig strand C	256..260	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	0/3 (0%)
		Ig strand F	300..305	CDD:409353	3/4 (75%)
Sdk1	NP_808547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		Ig_2	94..169	CDD:290606	20/94 (21%)
		IG_like	100..169	CDD:214653	19/88 (22%)
		IG_like	183..263	CDD:214653	23/84 (27%)
		Ig	197..247	CDD:299845	18/54 (33%)
		IG_like	281..357	CDD:214653	22/91 (24%)
		IGc2	294..347	CDD:197706	15/68 (22%)
		I-set	368..457	CDD:254352	1/1 (100%)
		Ig	388..454	CDD:143165
		I-set	462..552	CDD:254352
		Ig	476..552	CDD:299845
		I-set	557..646	CDD:254352
		Ig	562..646	CDD:299845
		FN3	650..741	CDD:238020
		fn3	753..839	CDD:278470
		FN3	854..949	CDD:238020
		FN3	954..1036	CDD:238020
		FN3	1052..1148	CDD:238020
		FN3	1158..1253	CDD:238020
		FN3	1261..1349	CDD:238020
		FN3	1360..1453	CDD:238020
		FN3	1459..1554	CDD:238020
		FN3	1562..1676	CDD:238020
		FN3	1686..1779	CDD:238020
		FN3	1784..1865	CDD:238020
		FN3	1885..1978	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2057..2080
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2187..2193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810