DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and Negr1

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_036019026.1 Gene:Negr1 / 320840 MGIID:2444846 Length:362 Species:Mus musculus


Alignment Length:342 Identity:104/342 - (30%)
Similarity:151/342 - (44%) Gaps:61/342 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 GGTVEFDCSVQYAKEYNVLFLKTD------------SDPVFLSTGSTLVIKDSRFSLRYDP---- 91
            |.:|:|    .:|...|:|..|.|            |...:|:..|.:.....::|:  ||    
Mouse    29 GQSVDF----PWAAVDNMLVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSV--DPRVSI 87

  Fly    92 ---NSSTYKLQIKDIQETDAGTYTCQVVISTVHKV-SAEVKLSVRRPPVISDNSTQSVVASEGSE 152
               |...|.|||:::..||.|.|||.|  .|.|.. :.:|.|:|:.||.|.|.|....: :||:.
Mouse    88 STLNKRDYSLQIQNVDVTDDGPYTCSV--QTQHTPRTMQVHLTVQVPPKIYDISNDMTI-NEGTN 149

  Fly   153 VQMECYASGYPTPTITWRRENNAILPTDSATYVGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRN 217
            |.:.|.|:|.|.|.|:||..:.:..|.::..|    |.|..:.::..|.|.|.|:|.||..|.:.
Mouse   150 VTLTCLATGKPEPVISWRHISPSAKPFENGQY----LDIYGITRDQAGEYECSAENDVSFPDVKK 210

  Fly   218 INVEVEFAPVI------TVPRPRLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQH-YSIS 275
            :.|.|.|||.|      ||...|.|.       :.|.....||||..|.|.:.:|.|.|. ..|.
Mouse   211 VRVIVNFAPTIQEIKSGTVTPGRSGL-------IRCEGAGVPPPAFEWYKGEKRLFNGQQGIIIQ 268

  Fly   276 HFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETIIPVC-------PPACGQA 333
            :|:|.     |.|.|..|.:..:|:|.|.|.|:.|...|.:.|.:.|.|..       .|:..|.
Mouse   269 NFSTR-----SILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNQIIEPTTSSPVTSPAPSTAQY 328

  Fly   334 YIAGA--EDVSATSFAL 348
            .|.|:  :..|..|.||
Mouse   329 GITGSACDLFSCWSLAL 345

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 30/107 (28%)
FR1 37..50 CDD:409353 3/6 (50%)
Ig strand A' 37..42 CDD:409353
Ig strand B 44..51 CDD:409353 2/6 (33%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 2/3 (67%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 3/13 (23%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 14/37 (38%)
Ig strand D 84..90 CDD:409353 1/5 (20%)
Ig strand E 94..102 CDD:409353 4/7 (57%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 2/8 (25%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 24/73 (33%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 29/97 (30%)
Ig strand C 256..260 CDD:409353 1/3 (33%)
Ig strand E 286..290 CDD:409353 2/3 (67%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
Negr1XP_036019026.1 FR1 38..55 CDD:409353 4/16 (25%)
Ig strand A' 40..46 CDD:409353 2/5 (40%)
IG_like 41..129 CDD:214653 26/91 (29%)
Ig strand B 48..56 CDD:409353 1/7 (14%)
CDR1 56..60 CDD:409353 0/3 (0%)
FR2 61..68 CDD:409353 2/6 (33%)
Ig strand C 61..67 CDD:409353 1/5 (20%)
CDR2 69..79 CDD:409353 1/9 (11%)
Ig strand C' 71..74 CDD:409353 0/2 (0%)
Ig strand C' 76..79 CDD:409353 0/2 (0%)
FR3 80..115 CDD:409353 15/38 (39%)
Ig strand D 84..91 CDD:409353 0/6 (0%)
Ig strand E 94..100 CDD:409353 3/5 (60%)
Ig strand F 107..115 CDD:409353 5/9 (56%)
CDR3 116..120 CDD:409353 2/3 (67%)
Ig strand G 120..129 CDD:409353 2/8 (25%)
FR4 122..129 CDD:409353 2/6 (33%)
Ig strand A' 139..144 CDD:409353 1/4 (25%)
IGc2 146..204 CDD:197706 20/61 (33%)
Ig strand B 150..157 CDD:409353 2/6 (33%)
Ig strand C 163..168 CDD:409353 2/4 (50%)
Ig strand C' 170..172 CDD:409353 0/1 (0%)
Ig strand E 180..186 CDD:409353 3/9 (33%)
Ig strand F 193..200 CDD:409353 3/6 (50%)
Ig_3 219..295 CDD:404760 27/87 (31%)
putative Ig strand A 219..225 CDD:409353 2/5 (40%)
Ig strand B 235..239 CDD:409353 1/10 (10%)
Ig strand C 248..252 CDD:409353 1/3 (33%)
Ig strand E 274..278 CDD:409353 2/3 (67%)
Ig strand F 288..293 CDD:409353 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833587
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H41447
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6406
SonicParanoid 1 1.000 - - X97
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.770

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