DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and Nrg

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster


Alignment Length:327 Identity:81/327 - (24%)
Similarity:125/327 - (38%) Gaps:73/327 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 TPTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDPN 92
            :||::::.||.|                                  .||...|.:||.:|  ||.
  Fly   163 SPTVNWMIQESI----------------------------------DGSIKSINNSRMTL--DPE 191

  Fly    93 SSTYKLQIKDIQETDAGT---YTCQV--VISTVHKVSAEVKLSVRR----------PPVISDNST 142
            .:   |...::...||.:   |.|..  |..:.:|:..:|.|.|::          |||....|.
  Fly   192 GN---LWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYVSR 253

  Fly   143 QSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSAT--YVGNTLRIKSVKKEDRGTYYCV 205
            :..:|..|..:::.|...|.|.|...|.::...|..:|..|  :.|.:|.|:....:|.|||.|.
  Fly   254 RQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCD 318

  Fly   206 ADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQ-YDMDLECHIEAYPPPAIVWT---KDDIQL 266
            ..|||......:|.:.|...|..| ..|.:..|.: .::..||.....|.|.|.|.   |...|.
  Fly   319 VSNGVGNAQSFSIILNVNSVPYFT-KEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQS 382

  Fly   267 ANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETIIPVCPPACG 331
            ..|...::         ||:|:|:|.:.|...|:|.|.|||..|.....|.|   .:...||...
  Fly   383 TPNPRRTV---------TDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYL---NVQAEPPTIS 435

  Fly   332 QA 333
            :|
  Fly   436 EA 437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 20/99 (20%)
FR1 37..50 CDD:409353 2/12 (17%)
Ig strand A' 37..42 CDD:409353 2/4 (50%)
Ig strand B 44..51 CDD:409353 0/6 (0%)
CDR1 51..59 CDD:409353 0/7 (0%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
FR2 60..63 CDD:409353 0/2 (0%)
CDR2 67..81 CDD:409353 2/13 (15%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 9/33 (27%)
Ig strand D 84..90 CDD:409353 2/5 (40%)
Ig strand E 94..102 CDD:409353 1/7 (14%)
Ig strand F 108..115 CDD:409353 3/9 (33%)
CDR3 116..124 CDD:409353 2/7 (29%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 22/75 (29%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 0/3 (0%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 3/4 (75%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 26/94 (28%)
Ig strand C 256..260 CDD:409353 1/3 (33%)
Ig strand E 286..290 CDD:409353 1/3 (33%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
NrgNP_001245581.1 Ig 55..128 CDD:299845
IG_like 57..127 CDD:214653
Ig 135..214 CDD:299845 18/89 (20%)
IG_like 141..216 CDD:214653 18/91 (20%)
ig 251..332 CDD:278476 22/80 (28%)
I-set 339..427 CDD:254352 28/100 (28%)
Ig 354..427 CDD:299845 24/84 (29%)
I-set 432..517 CDD:254352 2/6 (33%)
Ig 446..517 CDD:299845
I-set 522..611 CDD:254352
ig 525..609 CDD:278476
FN3 613..707 CDD:238020
FN3 716..807 CDD:238020
fn3 817..905 CDD:278470
FN3 917..1004 CDD:238020
FN3 1041..1111 CDD:238020
Bravo_FIGEY 1155..>1221 CDD:290593
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR12231
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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