DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and Igsf9b

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_001363879.1 Gene:Igsf9b / 315510 RGDID:1564717 Length:1441 Species:Rattus norvegicus


Alignment Length:291 Identity:74/291 - (25%)
Similarity:120/291 - (41%) Gaps:45/291 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 PVFLSTGSTLVIKDSRFSLR---YDPNSSTYKLQIKDIQETDAGTYTCQVVI-----STVHKVSA 125
            |:|:..|......|..::.|   :|..|    |:::.::..|.|.|.|:|::     .|.|. .:
  Rat    70 PIFIKFGYYPPHVDPEYAGRASLHDKAS----LRLEQVRSEDQGWYECKVLMLDQQYDTFHN-GS 129

  Fly   126 EVKLSVRRPPVISDNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSATYVGNTLR 190
            .|.|::..||..::...|.:.|.||..:.|.|.|.|.|.|.:||.:|...:..:........:|.
  Rat   130 WVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLSASGKYQVSDGSLT 194

  Fly   191 IKSVKKEDRGTYYCVADNGVSKGDR-RNINVEVEFAPVITVPRPRLGQALQYDMDLECHIEAYPP 254
            :.||.:||||.|.|.|.:  .:|:. ...::.|:..|.|..|...:...:..|..|.|..||||.
  Rat   195 VTSVSREDRGAYTCRAYS--IQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPG 257

  Fly   255 PAI---VWTKDDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEA---- 312
            ...   .|..:::...|:....:...      .|.||.:..|:....|.|.|..:|..|.:    
  Rat   258 NLTYTWYWQDENVYFQNDLKLRVRIL------IDGTLIIFRVKPEDAGKYTCVPSNSLGRSPSAS 316

  Fly   313 -------EARV-NLFETI-IPV-------CP 327
                   .||| |:...| :||       ||
  Rat   317 AYLTVQYPARVLNMPPVIYVPVGIHGYIRCP 347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 17/69 (25%)
FR1 37..50 CDD:409353
Ig strand A' 37..42 CDD:409353
Ig strand B 44..51 CDD:409353
CDR1 51..59 CDD:409353
Ig strand C 59..63 CDD:409353
FR2 60..63 CDD:409353
CDR2 67..81 CDD:409353 3/11 (27%)
Ig strand C' 68..72 CDD:409353 1/2 (50%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 8/33 (24%)
Ig strand D 84..90 CDD:409353 1/8 (13%)
Ig strand E 94..102 CDD:409353 1/7 (14%)
Ig strand F 108..115 CDD:409353 3/6 (50%)
CDR3 116..124 CDD:409353 2/12 (17%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 25/73 (34%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/3 (0%)
Ig 227..318 CDD:416386 23/105 (22%)
Ig strand C 256..260 CDD:409353 0/6 (0%)
Ig strand E 286..290 CDD:409353 2/3 (67%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
Igsf9bNP_001363879.1 PHA03247 <898..1246 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..1044
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1111..1332
Ig 41..115 CDD:319273 12/48 (25%)
I-set 139..225 CDD:369462 25/87 (29%)
Ig 229..321 CDD:386229 21/97 (22%)
Ig <353..414 CDD:386229
Ig 438..502 CDD:319273
FN3 510..605 CDD:238020
FN3 621..703 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 762..821
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 58 1.000 Domainoid score I10516
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12231
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.910

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