DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and DIP-alpha

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_001259218.1 Gene:DIP-alpha / 31322 FlyBaseID:FBgn0052791 Length:554 Species:Drosophila melanogaster


Alignment Length:323 Identity:97/323 - (30%)
Similarity:162/323 - (50%) Gaps:20/323 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LLLAIFVQQTLAQRTPT-ISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGST 77
            |||.:.:.:.:....|. :..|:...:. :|....|.|.|::...|.|.:||.|:..: .:....
  Fly    27 LLLIVSLLEAIGAFQPEFVESISNVSVA-VGRDATFTCHVRHLGGYRVGWLKADTKAI-QAIHEN 89

  Fly    78 LVIKDSRFSLRY-DPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPP-VISDN 140
            ::..:.|.::.: |.|  |:.|.||.:.|.|.|.|.||  ::|....|....|.|..|| .||::
  Fly    90 VITHNPRVTVSHLDQN--TWNLHIKAVSEEDRGGYMCQ--LNTDPMKSQIGFLDVVIPPDFISED 150

  Fly   141 STQSVVASEGSEVQMECYASGYPTPTITWRREN-NAILPTDSA-------TYVGNTLRIKSVKKE 197
            ::..|:..|||.|::.|.|.|||.|.:|||||: |.|:..|:.       ::.|..|::..:.:.
  Fly   151 TSSDVIVPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRN 215

  Fly   198 DRGTYYCVADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQYDMDLECHIEAYPPPAIVWTKD 262
            :.|:|.|:|.|||.....:.|::.:.|.|||.||...:|..|..|:.:|||:||.|.....|.||
  Fly   216 EMGSYLCIASNGVPPSVSKRISLSIHFHPVIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIKD 280

  Fly   263 DIQ-LANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETIIP 324
            ..: :..:..|.:...:.:...|..::.|...:|...|.|.|.|.|..||.::.:.|:|  ||
  Fly   281 TGEMIVTSGKYHVQESSQSMYETKMSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRLYE--IP 341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 25/95 (26%)
FR1 37..50 CDD:409353 2/12 (17%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 0/13 (0%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 12/31 (39%)
Ig strand D 84..90 CDD:409353 1/6 (17%)
Ig strand E 94..102 CDD:409353 3/7 (43%)
Ig strand F 108..115 CDD:409353 3/6 (50%)
CDR3 116..124 CDD:409353 1/7 (14%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 29/82 (35%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 27/91 (30%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 0/3 (0%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
DIP-alphaNP_001259218.1 IG_like 49..129 CDD:214653 22/85 (26%)
Ig 51..131 CDD:299845 23/85 (27%)
I-set 144..240 CDD:254352 32/95 (34%)
IGc2 159..228 CDD:197706 25/68 (37%)
Ig 244..337 CDD:299845 28/92 (30%)
I-set 244..337 CDD:254352 28/92 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40772
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR12231
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
65.920

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