DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and Kirrel1

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_006232737.1 Gene:Kirrel1 / 310695 RGDID:727883 Length:805 Species:Rattus norvegicus


Alignment Length:377 Identity:88/377 - (23%)
Similarity:134/377 - (35%) Gaps:88/377 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 STLLLAIFVQQTLAQRTPTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGS 76
            |||:...|..:.:....||.:        |||..|...|.........:.:.|.||     :.|.
  Rat   331 STLVNVHFAPRIVVYPKPTTT--------DIGSDVTLTCVWVGNPPLTLTWTKKDS-----NMGP 382

  Fly    77 TLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNS 141
            .|.......:|.....|::.:|.:|.:.:.|||||||:.::..:.....||.|.|..||:||..:
  Rat   383 RLPGSPPEANLSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEA 447

  Fly   142 TQSVVASEGSEVQMECYASGYPTP-TITWRRENN----------AILPTDSATYVGNTLRIKSVK 195
            .|..|..:|.:|  ||:....|.| .|.|..:.|          .:..|:|.:.|.:||.|.:|.
  Rat   448 VQFAVRGDGGKV--ECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVM 510

  Fly   196 KEDRGTYY-CVADNGVS---------------------------------------------KGD 214
            :.|..|:| |.|.|...                                             ||.
  Rat   511 EADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILLVFSFAALVFFLYRRRKGS 575

  Fly   215 RRNINVEVEFAPVITVPRPRLGQALQYDMDLECHIEAYPPPAIVWT--KDDIQLANNQHYSISHF 277
            |:::.:......|.||.|..|......:.|......|......:::  |||:.|..:.|  ....
  Rat   576 RKDVTLRKLDIKVETVNREPLTMHSDREDDTTSISTATRVMKAIYSSFKDDVDLKQDLH--CDTI 638

  Fly   278 ATADEY-----TDSTLRVITVEKRQ------YGDYVCKATNRF-GEAEARVN 317
            .|.:||     |:....|...|.|.      |.||......|| |...:|::
  Rat   639 ETREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPTRFDGRPSSRLS 690

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 24/94 (26%)
FR1 37..50 CDD:409353 4/12 (33%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 0/7 (0%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
FR2 60..63 CDD:409353 0/2 (0%)
CDR2 67..81 CDD:409353 3/13 (23%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 11/30 (37%)
Ig strand D 84..90 CDD:409353 1/5 (20%)
Ig strand E 94..102 CDD:409353 1/7 (14%)
Ig strand F 108..115 CDD:409353 6/6 (100%)
CDR3 116..124 CDD:409353 0/7 (0%)
FR4 124..130 CDD:409353 2/5 (40%)
Ig strand G 124..130 CDD:409353 2/5 (40%)
Ig_3 134..208 CDD:404760 27/85 (32%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 2/3 (67%)
Ig strand F 201..206 CDD:409353 3/5 (60%)
Ig strand G 215..218 CDD:409353 1/2 (50%)
Ig 227..318 CDD:416386 26/105 (25%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 0/3 (0%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
Kirrel1XP_006232737.1 I-set 54..148 CDD:254352
Ig 57..148 CDD:299845
Ig2_KIRREL3-like 170..251 CDD:143236
I-set 255..336 CDD:254352 3/4 (75%)
Ig_2 259..337 CDD:290606 3/5 (60%)
Ig_2 340..437 CDD:290606 26/109 (24%)
IG_like 346..437 CDD:214653 26/103 (25%)
Ig5_KIRREL3 439..536 CDD:143306 28/98 (29%)
IG_like 451..536 CDD:214653 23/86 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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