DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and Iglon5

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_218634.5 Gene:Iglon5 / 308557 RGDID:1305344 Length:336 Species:Rattus norvegicus


Alignment Length:317 Identity:93/317 - (29%)
Similarity:126/317 - (39%) Gaps:57/317 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 VQQTLAQRTPTISYITQEQIKDIGGTVEFDC-------SVQYAKEYNVLFLKTD---SDP---VF 71
            :.|:|...:|..:|...|     |......|       .|.:....|:|:...|   |||   :.
  Rat    29 LSQSLEFSSPADNYTVCE-----GDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLL 88

  Fly    72 LSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHK-VSAEVKLSVRRPP 135
            ::|                  ...:.:.|..:...|.|.|||.  ..|.|: .:.:|.|.|..|.
  Rat    89 INT------------------PEEFSILITQVGLGDEGLYTCS--FQTRHQPYTTQVYLIVHVPA 133

  Fly   136 VISDNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSATYVGNTLRIKSVKKEDRG 200
            .|. |.:..|..:||..|.:.|.|.|.|.||:|||:..      |..|..|..|.|..:::...|
  Rat   134 RIV-NISSPVAVNEGGNVNLLCLAVGRPEPTVTWRQLR------DGFTSEGEILEISDIQRGQAG 191

  Fly   201 TYYCVADNGV-SKGDRRNINVEVEFAPVI---TVPRPRLGQALQYDMDLECHIEAYPPPAIVWTK 261
            .|.||..||| |..|.|.:.|.|.:.|.|   |..|..||:|..    |.|...|.||....|.|
  Rat   192 EYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTALGRAAL----LRCEAMAVPPADFQWYK 252

  Fly   262 DDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNL 318
            ||..|::.   |........|.|.|.|....|..|.||:|.|:|.||.|.:.|.:.|
  Rat   253 DDRLLSSG---SAEGLKVQTERTRSMLLFANVSARHYGNYTCRAANRLGASSASMRL 306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 21/108 (19%)
FR1 37..50 CDD:409353 2/12 (17%)
Ig strand A' 37..42 CDD:409353 1/4 (25%)
Ig strand B 44..51 CDD:409353 1/13 (8%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 2/3 (67%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 4/16 (25%)
Ig strand C' 68..72 CDD:409353 2/6 (33%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 6/30 (20%)
Ig strand D 84..90 CDD:409353 0/5 (0%)
Ig strand E 94..102 CDD:409353 1/7 (14%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 2/8 (25%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 25/73 (34%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 2/3 (67%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 1/2 (50%)
Ig 227..318 CDD:416386 32/93 (34%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 2/3 (67%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
Iglon5XP_218634.5 Ig 41..129 CDD:416386 22/112 (20%)
Ig strand A' 41..46 CDD:409353 1/4 (25%)
Ig strand B 48..56 CDD:409353 1/7 (14%)
CDR1 56..60 CDD:409353 0/3 (0%)
FR2 61..68 CDD:409353 1/6 (17%)
Ig strand C 61..67 CDD:409353 1/5 (20%)
CDR2 69..79 CDD:409353 3/9 (33%)
Ig strand C' 71..74 CDD:409353 1/2 (50%)
Ig strand C' 76..79 CDD:409353 1/2 (50%)
FR3 80..115 CDD:409353 10/54 (19%)
Ig strand D 84..91 CDD:409353 0/6 (0%)
Ig strand E 94..100 CDD:409353 0/5 (0%)
Ig strand F 107..115 CDD:409353 4/9 (44%)
CDR3 116..120 CDD:409353 2/3 (67%)
Ig strand G 120..129 CDD:409353 2/8 (25%)
FR4 122..129 CDD:409353 2/6 (33%)
Ig strand A 132..137 CDD:409353 2/5 (40%)
Ig_3 134..199 CDD:404760 24/71 (34%)
Ig strand A' 140..145 CDD:409353 1/4 (25%)
Ig strand B 148..157 CDD:409353 2/8 (25%)
Ig strand C 163..167 CDD:409353 2/3 (67%)
Ig strand D 174..177 CDD:409353 1/2 (50%)
Ig strand E 178..183 CDD:409353 1/4 (25%)
Ig strand F 191..199 CDD:409353 4/7 (57%)
Ig_3 217..295 CDD:404760 29/84 (35%)
putative Ig strand A 218..224 CDD:409353 2/5 (40%)
Ig strand B 234..238 CDD:409353 1/7 (14%)
Ig strand C 247..251 CDD:409353 0/3 (0%)
Ig strand E 274..278 CDD:409353 2/3 (67%)
Ig strand F 288..293 CDD:409353 2/4 (50%)
Ig strand G 301..304 CDD:409353 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166337177
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X97
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.750

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