DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and Ncam2

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_981954.2 Gene:Ncam2 / 288280 RGDID:1303131 Length:837 Species:Rattus norvegicus


Alignment Length:327 Identity:84/327 - (25%)
Similarity:133/327 - (40%) Gaps:56/327 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 STLLLAIFVQ--QTLAQRTPTISYITQEQIKDIGGTVEFDCSVQYAKE----YNVLFLKTDSDPV 70
            |..||.:.|.  |.|.|.|.::|.:.    ..:|.:..|.|:.....|    ||      .....
  Rat     6 SFYLLGLLVSSGQALLQVTISLSKVE----LSVGESKFFTCTAIGEPESIDWYN------PQGEK 60

  Fly    71 FLSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEV------KL 129
            .:||...::.|:...|          :|.|.:....|||.|.||...:......|.|      ||
  Rat    61 IISTQRVMLQKEGVRS----------RLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKL 115

  Fly   130 SVRRPPVISDNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAI--LPTDS-ATYVGNTLRI 191
            :.|.  |:|....:     :|.:.::.|..|..|.|.::|...|..:  :|.:. |....|.|:|
  Rat   116 TFRE--VLSPQEFK-----QGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIPDNRFAVLANNNLQI 173

  Fly   192 KSVKKEDRGTYYC---VADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQ--YDMDLECHIEA 251
            .::.|.|.|.|.|   |...|  :.|.|:|.|.|...|.|.:|:.......:  .:|.|.|....
  Rat   174 LNINKSDEGIYRCEGRVEARG--EIDFRDIIVIVNVPPAIVMPQKSFNATAERGEEMTLTCKASG 236

  Fly   252 YPPPAIVWTKDDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARV 316
            .|.|||.|.::...:..|:.|.:       :.:::.|.|..:..:..|.|||||||:.||.:.:.
  Rat   237 SPDPAISWFRNGKLIEENEKYIL-------KGSNTELTVRNIINKDGGSYVCKATNKAGEDQKQA 294

  Fly   317 NL 318
            .|
  Rat   295 FL 296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 22/104 (21%)
FR1 37..50 CDD:409353 2/12 (17%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 1/11 (9%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 0/2 (0%)
CDR2 67..81 CDD:409353 2/13 (15%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 8/30 (27%)
Ig strand D 84..90 CDD:409353 1/5 (20%)
Ig strand E 94..102 CDD:409353 2/7 (29%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 0/7 (0%)
FR4 124..130 CDD:409353 3/11 (27%)
Ig strand G 124..130 CDD:409353 3/11 (27%)
Ig_3 134..208 CDD:404760 20/79 (25%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 0/3 (0%)
Ig strand E 187..191 CDD:409353 2/3 (67%)
Ig strand F 201..206 CDD:409353 2/7 (29%)
Ig strand G 215..218 CDD:409353 1/2 (50%)
Ig 227..318 CDD:416386 24/92 (26%)
Ig strand C 256..260 CDD:409353 2/3 (67%)
Ig strand E 286..290 CDD:409353 1/3 (33%)
Ig strand F 300..305 CDD:409353 3/4 (75%)
Ncam2NP_981954.2 IgI_1_NCAM-2 21..113 CDD:409452 23/111 (21%)
Ig strand B 38..42 CDD:409452 1/3 (33%)
Ig strand C 50..54 CDD:409452 0/3 (0%)
Ig strand E 76..80 CDD:409452 2/13 (15%)
Ig strand F 90..95 CDD:409452 2/4 (50%)
Ig strand G 104..107 CDD:409452 1/2 (50%)
IGc2 128..189 CDD:197706 17/60 (28%)
Ig strand B 130..139 CDD:409353 1/8 (13%)
Ig strand C 145..153 CDD:409353 1/7 (14%)
Ig strand C' 156..159 CDD:409353 0/2 (0%)
Ig strand D 162..167 CDD:409353 1/4 (25%)
Ig strand E 168..175 CDD:409353 3/6 (50%)
IgI_1_MuSK 209..298 CDD:409562 26/95 (27%)
Ig strand B 228..232 CDD:409562 2/3 (67%)
Ig strand C 241..245 CDD:409562 2/3 (67%)
Ig strand E 264..268 CDD:409562 1/3 (33%)
Ig strand F 278..283 CDD:409562 3/4 (75%)
Ig strand G 291..294 CDD:409562 0/2 (0%)
Ig 300..397 CDD:416386
Ig strand A 300..305 CDD:409353
Ig strand A' 309..313 CDD:409353
Ig strand B 317..325 CDD:409353
Ig strand C 331..337 CDD:409353
Ig strand C' 340..343 CDD:409353
Ig strand D 353..359 CDD:409353
Ig strand E 362..368 CDD:409353
Ig strand F 376..384 CDD:409353
Ig strand G 387..397 CDD:409353
Ig_3 401..479 CDD:404760
Ig strand B 418..422 CDD:409353
Ig strand C 431..435 CDD:409353
Ig strand E 458..462 CDD:409353
Ig strand F 472..477 CDD:409353
Ig strand G 486..489 CDD:409353
FN3 496..588 CDD:238020
fn3 594..678 CDD:394996
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12231
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.000

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