DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and PRTG

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_776175.2	Gene:	PRTG / 283659	HGNCID:	26373	Length:	1150	Species:	Homo sapiens

Alignment Length:	357	Identity:	82/357 - (22%)
Similarity:	131/357 - (36%)	Gaps:	89/357 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ISYITQEQIKDI------GGTVEFDCSVQ------YAKEYNVLFLKTDSDPV-FLSTGSTLVIKD 82
            :|.|:..:::.|      ||...|.|.:.      ...|:|...|....|.: .|.||
Human   131 LSTISAFEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTG------- 188

  Fly    83 SRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHK----------VSAEVKLSVRRPPVI 137
                          .|||.|:.:.|:|.|.| :..:..|:          :.|:...|...|.:|
Human   189 --------------VLQIYDVSQRDSGNYRC-IAATVAHRRKSMEASLTVIPAKESKSFHTPTII 238

  Fly   138 SDNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSATYVGN-TLRIKSVKKEDRGT 201
            :  ..|::..|....|.:||.|:|.|.|.|:|.|.::..:...:...:|| .|.|..|:.:..|.
Human   239 A--GPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGV 301

  Fly   202 YYCVADNGVSKGDRRNINVEVEFAPVITVP----------RPRLGQALQYDMDLECHIEAYPPPA 256
            |.|.|    :....||..|.:....|:..|          |||.|.|     ...|..|..|.|.
Human   302 YVCRA----TTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTA-----RFVCQAEGIPSPK 357

  Fly   257 IVWTKDDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFET 321
            :.|.|:..::.:|....:         .:|.|.:..:.......|.|.|.|..|...:|..|  |
Human   358 MSWLKNGRKIHSNGRIKM---------YNSKLVINQIIPEDDAIYQCMAENSQGSILSRARL--T 411

  Fly   322 II-----PVCPPACGQAYIAGAEDVSATSFAL 348
            ::     |..|      |...||.:|:::..|
Human   412 VVMSEDRPSAP------YNVHAETMSSSAILL 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	22/117 (19%)
		FR1	37..50	CDD:409353	4/18 (22%)
		Ig strand A'	37..42	CDD:409353	0/4 (0%)
		Ig strand B	44..51	CDD:409353	2/6 (33%)
		CDR1	51..59	CDD:409353	1/13 (8%)
		Ig strand C	59..63	CDD:409353	1/3 (33%)
		FR2	60..63	CDD:409353	0/2 (0%)
		CDR2	67..81	CDD:409353	4/14 (29%)
		Ig strand C'	68..72	CDD:409353	1/4 (25%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	8/30 (27%)
		Ig strand D	84..90	CDD:409353	0/5 (0%)
		Ig strand E	94..102	CDD:409353	3/7 (43%)
		Ig strand F	108..115	CDD:409353	3/6 (50%)
		CDR3	116..124	CDD:409353	1/17 (6%)
		FR4	124..130	CDD:409353	1/5 (20%)
		Ig strand G	124..130	CDD:409353	1/5 (20%)
		Ig_3	134..208	CDD:404760	23/74 (31%)
		Ig strand B	153..157	CDD:409353	1/3 (33%)
		Ig strand C	166..170	CDD:409353	1/3 (33%)
		Ig strand E	187..191	CDD:409353	2/4 (50%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	1/2 (50%)
		Ig	227..318	CDD:416386	22/100 (22%)
		Ig strand C	256..260	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	2/3 (67%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
PRTG	NP_776175.2	Ig	40..130	CDD:299845
		Ig	139..223	CDD:299845	21/105 (20%)
		IG_like	141..223	CDD:214653	21/103 (20%)
		IG_like	241..323	CDD:214653	24/85 (28%)
		IGc2	250..309	CDD:197706	19/62 (31%)
		I-set	327..412	CDD:254352	22/100 (22%)
		Ig	345..412	CDD:299845	16/77 (21%)
		FN3	419..512	CDD:238020	7/25 (28%)
		FN3	517..610	CDD:238020
		fn3	624..699	CDD:278470
		FN3	726..814	CDD:238020
		FN3	821..911	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	981..1002
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1086..1150
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100