DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and LRIT1

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_056428.1	Gene:	LRIT1 / 26103	HGNCID:	23404	Length:	623	Species:	Homo sapiens

Alignment Length:	196	Identity:	43/196 - (21%)
Similarity:	68/196 - (34%)	Gaps:	62/196 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 GSEVQMECYASGYPTPTITWRRENNAIL--------PTDSATYVGNTLRIKSVKKEDRGTYYCVA 206
            |....:.|.|:|.|.|.::|||.|...|        .:|..::  ..|.:.:|...|.|.|.|.|
Human   268 GGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSW--TLLGLPAVSHLDSGDYICQA 330

  Fly   207 DN--GVSKGDRRNINVEVEFAPVITVPRPRL----------------GQALQYDMDLEC-HIEAY 252
            .|  |.|         |...:.::|.|....                |:|..|:..|.. |:...
Human   331 KNFLGAS---------ETVISLIVTEPPTSTEHSGSPGALWARTGGGGEAAAYNNKLVARHVPQI 386

  Fly   253 PPPAIVWTKDDIQLANNQHYSISHFA--TADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEAR 315
            |.||::.|...:. :..:..::.||.  ...|.:|                     .|.|.:|||
Human   387 PKPAVLATGPSVP-STKEELTLEHFQMDALGELSD---------------------GRAGPSEAR 429

  Fly   316 V 316
            :
Human   430 M 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653
		FR1	37..50	CDD:409353
		Ig strand A'	37..42	CDD:409353
		Ig strand B	44..51	CDD:409353
		CDR1	51..59	CDD:409353
		Ig strand C	59..63	CDD:409353
		FR2	60..63	CDD:409353
		CDR2	67..81	CDD:409353
		Ig strand C'	68..72	CDD:409353
		Ig strand C'	79..81	CDD:409353
		FR3	84..115	CDD:409353
		Ig strand D	84..90	CDD:409353
		Ig strand E	94..102	CDD:409353
		Ig strand F	108..115	CDD:409353
		CDR3	116..124	CDD:409353
		FR4	124..130	CDD:409353
		Ig strand G	124..130	CDD:409353
		Ig_3	134..208	CDD:404760	19/65 (29%)
		Ig strand B	153..157	CDD:409353	0/3 (0%)
		Ig strand C	166..170	CDD:409353	0/3 (0%)
		Ig strand E	187..191	CDD:409353	1/3 (33%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	20/109 (18%)
		Ig strand C	256..260	CDD:409353	1/3 (33%)
		Ig strand E	286..290	CDD:409353	0/3 (0%)
		Ig strand F	300..305	CDD:409353	0/4 (0%)
LRIT1	NP_056428.1	LRR 1	60..81
		leucine-rich repeat	61..84	CDD:275378
		LRR_8	63..143	CDD:290566
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..129
		LRR_8	131..202	CDD:290566
		LRR_4	131..171	CDD:289563
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378
		LRR 5	156..177
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..205	CDD:275378
		TPKR_C2	201..>240	CDD:301599
		Ig	267..345	CDD:299845	23/87 (26%)
		IG_like	267..345	CDD:214653	23/87 (26%)
		FN3	431..498	CDD:214495	43/196 (22%)
		LRR 6. /evidence=ECO:0000305	571..594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900