Protein Alignment Lac and NEGR1

DIOPT Version :10

• Sequence 1: NP_523713.2
• Gene: Lac / 36363
• FlyBaseID: FBgn0010238
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: NP_776169.2
• Gene: NEGR1 / 257194
• HGNCID: 17302
• Length: 354
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 105/339 - (30%)
• Similarity: 155/339 - (45%)
• Gaps: 59/339 - (17%)

  Fly    43 GGTVEFDCSVQYAKEYNVLFLKTD------------SDPVFLSTGSTLVIKDSRFSLRYDP---- 91
            |.:|:|    .:|...|::..|.|            |...:|:..|.:.....::|:  ||
Human    35 GQSVDF----PWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSV--DPRVSI 93

  Fly    92 ---NSSTYKLQIKDIQETDAGTYTCQVVISTVHKV-SAEVKLSVRRPPVISDNSTQSVVASEGSE 152
               |...|.|||:::..||.|.|||.|  .|.|.. :.:|.|:|:.||.|.|.|....| :||:.
Human    94 STLNKRDYSLQIQNVDVTDDGPYTCSV--QTQHTPRTMQVHLTVQVPPKIYDISNDMTV-NEGTN 155

  Fly   153 VQMECYASGYPTPTITWRRENNAILPTDSATYVGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRN 217
            |.:.|.|:|.|.|:|:||..:.:..|.::..|    |.|..:.::..|.|.|.|:|.||..|.|.
Human   156 VTLTCLATGKPEPSISWRHISPSAKPFENGQY----LDIYGITRDQAGEYECSAENDVSFPDVRK 216

  Fly   218 INVEVEFAPVI------TVPRPRLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQH-YSIS 275
            :.|.|.|||.|      ||...|.|.       :.|.....||||..|.|.:.:|.|.|. ..|.
Human   217 VKVVVNFAPTIQEIKSGTVTPGRSGL-------IRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQ 274

  Fly   276 HFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETIIPVCPPACGQAYIAGAED 340
            :|:|.     |.|.|..|.:..:|:|.|.|.|:.|...|.       :|:.||:..|..|.|:.|
Human   275 NFSTR-----SILTVTNVTQEHFGNYTCVAANKLGTTNAS-------LPLNPPSTAQYGITGSAD 327

  Fly   341 VSATSFALVGILAA 354
            |..:.:.||..|::
Human   328 VLFSCWYLVLTLSS 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	29/107 (27%)
		Ig strand B	46..50	CDD:409381	2/3 (67%)
		Ig strand C	60..63	CDD:409381	0/2 (0%)
		Ig strand E	96..100	CDD:409381	2/3 (67%)
		Ig strand F	110..115	CDD:409381	3/4 (75%)
		Ig strand G	124..127	CDD:409381	0/2 (0%)
		Ig_3	134..208	CDD:464046	25/73 (34%)
		Ig	227..318	CDD:472250	29/97 (30%)
		Ig strand C	256..260	CDD:409353	1/3 (33%)
		Ig strand E	286..290	CDD:409353	2/3 (67%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
NEGR1	NP_776169.2	IG_like	47..135	CDD:214653	25/91 (27%)
		Ig strand B	56..60	CDD:409353	0/3 (0%)
		Ig strand C	68..72	CDD:409353	0/3 (0%)
		Ig strand E	101..105	CDD:409353	2/3 (67%)
		Ig strand F	115..120	CDD:409353	3/4 (75%)
		Ig strand G	128..131	CDD:409353	0/2 (0%)
		Ig_3	138..207	CDD:464046	25/73 (34%)
		IG_like	231..312	CDD:214653	28/99 (28%)
		Ig strand B	241..245	CDD:409353	1/10 (10%)
		Ig strand C	254..258	CDD:409353	1/3 (33%)
		Ig strand E	280..284	CDD:409353	2/3 (67%)
		Ig strand F	294..299	CDD:409353	2/4 (50%)