DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and HEPACAM2

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_001275733.1 Gene:HEPACAM2 / 253012 HGNCID:27364 Length:485 Species:Homo sapiens


Alignment Length:280 Identity:72/280 - (25%)
Similarity:111/280 - (39%) Gaps:62/280 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 LFLKTDSDPVFLSTGST--LVIKDSRFSLRY---DPNSSTYKLQIKDIQETDAGTYTCQVVISTV 120
            ||.:..:.|.:| .||.  .|:.|..:..::   .||:|   |.|..:|..|.|.|..:|.|...
Human    92 LFERPHTMPKYL-LGSVNKSVVPDLEYQHKFTMMPPNAS---LLINPLQFPDEGNYIVKVNIQGN 152

  Fly   121 HKVSAEVKLSVR-----RPPVISDNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTD 180
            ..:||..|:.|.     ..||:..:.....|...|: :.:.|:..|.......|.:....:  ..
Human   153 GTLSASQKIQVTVDDPVTKPVVQIHPPSGAVEYVGN-MTLTCHVEGGTRLAYQWLKNGRPV--HT 214

  Fly   181 SATY----VGNTLRIKSVKKEDRGTYYCVADNGVSK---------------GDRRNINVEVEFAP 226
            |:||    ..|||.|..|.|||.|.|.|:..|.||:               |.:.|.:..::...
Human   215 SSTYSFSPQNNTLHIAPVTKEDIGNYSCLVRNPVSEMESDIIMPIIYYGPYGLQVNSDKGLKVGE 279

  Fly   227 VITVPRPRLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQHYSISH----FATADEYTDST 287
            |.||.   ||:|:.:|    |..:::||....|    |:..:|..|.|.|    ...:::....|
Human   280 VFTVD---LGEAILFD----CSADSHPPNTYSW----IRRTDNTTYIIKHGPRLEVASEKVAQKT 333

  Fly   288 LRVITVEKRQYGDYVCKATN 307
            :           ||||.|.|
Human   334 M-----------DYVCCAYN 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 22/74 (30%)
FR1 37..50 CDD:409353
Ig strand A' 37..42 CDD:409353
Ig strand B 44..51 CDD:409353
CDR1 51..59 CDD:409353
Ig strand C 59..63 CDD:409353 1/1 (100%)
FR2 60..63 CDD:409353 1/1 (100%)
CDR2 67..81 CDD:409353 5/15 (33%)
Ig strand C' 68..72 CDD:409353 1/3 (33%)
Ig strand C' 79..81 CDD:409353 1/1 (100%)
FR3 84..115 CDD:409353 9/33 (27%)
Ig strand D 84..90 CDD:409353 0/8 (0%)
Ig strand E 94..102 CDD:409353 3/7 (43%)
Ig strand F 108..115 CDD:409353 2/6 (33%)
CDR3 116..124 CDD:409353 1/7 (14%)
FR4 124..130 CDD:409353 3/5 (60%)
Ig strand G 124..130 CDD:409353 3/5 (60%)
Ig_3 134..208 CDD:404760 21/77 (27%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 0/3 (0%)
Ig strand E 187..191 CDD:409353 3/3 (100%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 23/85 (27%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 1/3 (33%)
Ig strand F 300..305 CDD:409353 4/4 (100%)
HEPACAM2NP_001275733.1 Ig 128..>197 CDD:299845 18/72 (25%)
I-set 172..255 CDD:254352 24/85 (28%)
IGc2 190..249 CDD:197706 18/60 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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