DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and Lrit1

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_647547.2	Gene:	Lrit1 / 246214	RGDID:	628607	Length:	623	Species:	Rattus norvegicus

Alignment Length:	450	Identity:	85/450 - (18%)
Similarity:	144/450 - (32%)	Gaps:	173/450 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 NVLFLKTDSDPVF------------LSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTY 111
            |:.||...::.:.            |.||..|..:.:|..|....|......::.|:.....|..
  Rat   156 NLTFLDLSNNQLMRLPEELLDTWAHLKTGPYLSSRRTRLVLGLQDNPWVCDCRLYDLVHLLDGWA 220

  Fly   112 TCQVVI----------STVHKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQMECYASGYPTPT 166
            :..:.|          |......::::|...:.|.:....| |:::..||.|.:.|.|:|.|.|.
  Rat   221 SNLIFIEARLRCGSPRSLAGVAFSQLELRKCQSPELRPGVT-SIISPLGSTVLLRCGATGIPGPE 284

  Fly   167 ITWRRENNAIL--------PTDSATYVGNTLRIKSVKKEDRGTYYCVADN--GVSKGDRRNINVE 221
            ::|||.|...|        .:|.:::  ..|.:..|...|.|.|.|.|.|  |.|         |
  Rat   285 MSWRRANGRPLNGTVHQEVSSDGSSW--TLLDLPVVSLFDSGDYICQAKNFLGAS---------E 338

  Fly   222 VEFAPVITVPR-------------PRLG---QALQYDMDLEC-HIEAYPPPAIVWT-------KD 262
            ...:.::|.|:             .|.|   :|..|:..|.. |:...|.|..:.|       |:
  Rat   339 TLISLIVTEPQTSTEYTGIPGALWARTGEGAEAAAYNNKLVARHVPHVPEPVALATKPSVPSIKE 403

  Fly   263 DIQLANNQ-----------------------------HYSISHFATADEYTDST----------- 287
            ::.|.|.|                             ::|:|....|.:..::|
  Rat   404 ELPLQNFQMDVPGEFSREPSEHQETQMVRSLKVVGDTYHSVSLVWKAPQAGNTTAFSVLYAVFGQ 468

  Fly   288 --LRVITVE-------------KRQYGDYVCK-------------ATNRFGEAEARVNLFETI-- 322
              :|.:|||             |.:|...||.             :|:...:||....|...:
  Rat   469 RDMRRMTVEAGKTSVTIEGLAPKTKYVACVCVRGLVPTKEQCVIFSTDEVVDAEGTQRLINMVVI 533

  Fly   323 ----IPVCPP----ACGQ------------------AYI---------AGAEDVSATSFA 347
                |...||    .||.                  ||:         .|:|::|.:|.:
  Rat   534 SVAAIIALPPTLLVCCGALRRRCHKCRAGGSAEASGAYVNLERLGHSEDGSEELSRSSLS 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	15/93 (16%)
		FR1	37..50	CDD:409353
		Ig strand A'	37..42	CDD:409353
		Ig strand B	44..51	CDD:409353
		CDR1	51..59	CDD:409353	85/449 (19%)
		Ig strand C	59..63	CDD:409353	1/3 (33%)
		FR2	60..63	CDD:409353	0/2 (0%)
		CDR2	67..81	CDD:409353	4/25 (16%)
		Ig strand C'	68..72	CDD:409353	0/15 (0%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	5/30 (17%)
		Ig strand D	84..90	CDD:409353	2/5 (40%)
		Ig strand E	94..102	CDD:409353	0/7 (0%)
		Ig strand F	108..115	CDD:409353	1/6 (17%)
		CDR3	116..124	CDD:409353	2/17 (12%)
		FR4	124..130	CDD:409353	0/5 (0%)
		Ig strand G	124..130	CDD:409353	0/5 (0%)
		Ig_3	134..208	CDD:404760	24/81 (30%)
		Ig strand B	153..157	CDD:409353	1/3 (33%)
		Ig strand C	166..170	CDD:409353	0/3 (0%)
		Ig strand E	187..191	CDD:409353	1/3 (33%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	30/182 (16%)
		Ig strand C	256..260	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	1/16 (6%)
		Ig strand F	300..305	CDD:409353	2/17 (12%)
Lrit1	NP_647547.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..128
		LRR_8	131..>176	CDD:290566	3/19 (16%)
		LRR_4	131..172	CDD:289563	3/15 (20%)
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378	85/449 (19%)
		LRR 5	156..177		3/20 (15%)
		leucine-rich repeat	157..180	CDD:275378	2/22 (9%)
		leucine-rich repeat	181..205	CDD:275378	7/23 (30%)
		TPKR_C2	201..>240	CDD:301599	5/38 (13%)
		Ig	257..345	CDD:299845	27/99 (27%)
		IG_like	267..345	CDD:214653	25/88 (28%)
		FN3	431..501	CDD:214495	12/69 (17%)
		LRR 6	525..548		4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900