DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and Lrit3

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_001274153.1	Gene:	Lrit3 / 242235	MGIID:	2685267	Length:	681	Species:	Mus musculus

Alignment Length:	277	Identity:	60/277 - (21%)
Similarity:	94/277 - (33%)	Gaps:	108/277 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SVQYAKEYNVLFLK----TDSDPVFLSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTY 111
            :|:|.:....|.|.    |...|.||.:.|.|.:..|| |..:.|......||        ...:
Mouse   148 AVRYLRNLTCLDLSSNRLTTLPPDFLDSWSHLAVTPSR-SPDFPPRRIILGLQ--------DNPW 203

  Fly   112 TCQVVISTVHKVS---------------------------AEVKLSVRRPPVISDNSTQSVVASE 149
            .|...||.|.::|                           ..|:|.....|.:..::|: :.::.
Mouse   204 FCDCHISKVIELSKVTDHAVVLLDPLMVCSEPERFQGILFQRVELEKCLKPSVMMSATK-ITSAL 267

  Fly   150 GSEVQMECYASGYPTPTITWRRENNAILPTDSATYV----GNTLR-----IKSVKKEDRGTYYCV 205
            ||.|.:.|.|.|:|||.:||.|.:.:   |.:.|.:    |..:|     :.|:..:|.|.|.|.
Mouse   268 GSNVLLRCDAKGHPTPQLTWTRSDGS---TVNYTVIQESPGEGIRWSIISLTSISHKDAGDYRCK 329

  Fly   206 ADN--GVSKGDRRNINVEVEFAPVITV--------------------------PRPRLGQALQYD 242
            |.|  |:|:.             |:||                          |:|.||.:
Mouse   330 AKNLAGISEA-------------VVTVTVVGGVTTTLSPDSSERSPGEPPEQHPQPGLGGS---- 377

  Fly   243 MDLECHIEAYPPPAIVW 259
                      .||:..|
Mouse   378 ----------TPPSKSW 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	23/110 (21%)
		FR1	37..50	CDD:409353
		Ig strand A'	37..42	CDD:409353
		Ig strand B	44..51	CDD:409353	60/277 (22%)
		CDR1	51..59	CDD:409353	2/7 (29%)
		Ig strand C	59..63	CDD:409353	1/3 (33%)
		FR2	60..63	CDD:409353	1/2 (50%)
		CDR2	67..81	CDD:409353	5/13 (38%)
		Ig strand C'	68..72	CDD:409353	1/3 (33%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	6/30 (20%)
		Ig strand D	84..90	CDD:409353	2/5 (40%)
		Ig strand E	94..102	CDD:409353	2/7 (29%)
		Ig strand F	108..115	CDD:409353	1/6 (17%)
		CDR3	116..124	CDD:409353	3/7 (43%)
		FR4	124..130	CDD:409353	2/32 (6%)
		Ig strand G	124..130	CDD:409353	2/32 (6%)
		Ig_3	134..208	CDD:404760	24/82 (29%)
		Ig strand B	153..157	CDD:409353	1/3 (33%)
		Ig strand C	166..170	CDD:409353	1/3 (33%)
		Ig strand E	187..191	CDD:409353	1/8 (13%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	10/59 (17%)
		Ig strand C	256..260	CDD:409353	1/4 (25%)
		Ig strand E	286..290	CDD:409353
		Ig strand F	300..305	CDD:409353
Lrit3	NP_001274153.1	LRR 1. /evidence=ECO:0000255	56..79
		LRR_8	61..117	CDD:290566
		LRR 2. /evidence=ECO:0000255	80..103
		leucine-rich repeat	83..106	CDD:275378
		LRR 3. /evidence=ECO:0000255	104..128
		LRR_8	105..165	CDD:290566	4/16 (25%)
		LRR_4	106..146	CDD:289563
		leucine-rich repeat	107..130	CDD:275378
		LRR_4	129..170	CDD:289563	5/21 (24%)
		LRR 4. /evidence=ECO:0000255	129..151		1/2 (50%)
		leucine-rich repeat	131..154	CDD:275378	2/5 (40%)
		LRR 5. /evidence=ECO:0000255	152..175		6/22 (27%)
		leucine-rich repeat	155..168	CDD:275378	3/12 (25%)
		Ig	254..335	CDD:299845	25/84 (30%)
		IG_like	263..339	CDD:214653	25/78 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..391		7/49 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..464
		FN3	489..563	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900