DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and Vcam1

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_035823.3	Gene:	Vcam1 / 22329	MGIID:	98926	Length:	739	Species:	Mus musculus

Alignment Length:	443	Identity:	93/443 - (20%)
Similarity:	155/443 - (34%)	Gaps:	167/443 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VQQTLAQRTPTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLF-LKTDSDPV-FLSTGSTLVIKD 82
            :|..::.|..|||.....:::: ||.|...||.:......:.: .|.|::.: .||..:||.:
Mouse   217 LQVYISPRNTTISVHPSTRLQE-GGAVTMTCSSEGLPAPEIFWGRKLDNEVLQLLSGNATLTL-- 278

  Fly    83 SRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQSVVA 147
              .::|.:                |:|.|.|:.| :.:.:..|||:|.|:..|.|.|.|..|.||
Mouse   279 --IAMRME----------------DSGVYVCEGV-NLIGRDKAEVELVVQEKPFIVDISPGSQVA 324

  Fly   148 SE-GSEVQMECYASGYPTPTITWRREN----NAILPTDSATYVGNTLRIKSVKKEDRGTYYCVAD 207
            :: |..|.:.|.|.|..:|:.:||.:.    |.::..:.|.   :||.:.||..||..:|.| |.
Mouse   325 AQVGDSVVLTCAAIGCDSPSFSWRTQTDSPLNGVVRNEGAK---STLVLSSVGFEDEHSYLC-AV 385

  Fly   208 NGVSKGDRRNINVEV-EFA--PVI----------------TVP---------------------- 231
            ..:.:...:...||| .|.  |||                |||
Mouse   386 TCLQRTLEKRTQVEVYSFPEDPVIKMSGPLVHGRPVTVNCTVPNVYPFDHLEIELLKGETTLMKK 450

  Fly   232 --------------------------------------------RPRLGQALQ------------ 240
                                                        .|:..|::|
Mouse   451 YFLEEMGIKSLETKILETTFIPTIEDTGKSLVCLARLHSGEMESEPKQRQSVQPLYVNVAPKETT 515

  Fly   241 ------------YDMDLECHIEAYPPPAIVWTKDDIQLANNQHYSISHFATADEYTDSTLRVITV 293
                        ..::|.|..:..|.|.|:|::   ||.|.:...:|.        ::||..::.
Mouse   516 IWVSPSPILEEGSPVNLTCSSDGIPAPKILWSR---QLNNGELQPLSE--------NTTLTFMST 569

  Fly   294 EKRQYGDYVCKATNRFGEAEARVNLFETIIPVCPPACGQAYIAGAEDVSATSF 346
            ::...|.|||:..|..|.:...|   |.||.|.|           :|:..|.|
Mouse   570 KRDDSGIYVCEGINEAGISRKSV---ELIIQVSP-----------KDIQLTVF 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	21/96 (22%)
		FR1	37..50	CDD:409353	3/12 (25%)
		Ig strand A'	37..42	CDD:409353	0/4 (0%)
		Ig strand B	44..51	CDD:409353	2/6 (33%)
		CDR1	51..59	CDD:409353	1/7 (14%)
		Ig strand C	59..63	CDD:409353	0/4 (0%)
		FR2	60..63	CDD:409353	0/3 (0%)
		CDR2	67..81	CDD:409353	4/14 (29%)
		Ig strand C'	68..72	CDD:409353	0/4 (0%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	5/30 (17%)
		Ig strand D	84..90	CDD:409353	1/5 (20%)
		Ig strand E	94..102	CDD:409353	0/7 (0%)
		Ig strand F	108..115	CDD:409353	3/6 (50%)
		CDR3	116..124	CDD:409353	1/7 (14%)
		FR4	124..130	CDD:409353	3/5 (60%)
		Ig strand G	124..130	CDD:409353	3/5 (60%)
		Ig_3	134..208	CDD:404760	26/78 (33%)
		Ig strand B	153..157	CDD:409353	1/3 (33%)
		Ig strand C	166..170	CDD:409353	0/3 (0%)
		Ig strand E	187..191	CDD:409353	2/3 (67%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	27/196 (14%)
		Ig strand C	256..260	CDD:409353	1/3 (33%)
		Ig strand E	286..290	CDD:409353	2/3 (67%)
		Ig strand F	300..305	CDD:409353	3/4 (75%)
Vcam1	NP_035823.3	IG_like	35..110	CDD:214653
		IGc2	39..98	CDD:197706
		Ig2_VCAM-1	116..214	CDD:143313
		IG_like	232..308	CDD:214653	21/97 (22%)
		IGc2	238..298	CDD:197706	17/81 (21%)
		IG_like	321..400	CDD:214653	23/82 (28%)
		IGc2	328..386	CDD:197706	19/61 (31%)
		Ig2_VCAM-1	404..502	CDD:143313	8/97 (8%)
		Ig_2	514..596	CDD:290606	20/95 (21%)
		IG_like	519..596	CDD:214653	20/90 (22%)
		Ig	598..685	CDD:299845	5/22 (23%)
		IG_like	609..685	CDD:214653	93/443 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910