DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and SDK1

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:338 Identity:83/338 - (24%)
Similarity:136/338 - (40%) Gaps:69/338 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 WSTLLLAIFVQQTLAQRTPTISYITQEQIKDI---GGTVEFDCSVQYAKEYNVLFLKTDSDPVFL 72
            |:.|.|.:.:.:.|||......:.|:..:..|   |..:...|..:.:......:::.||:   |
Human    84 WALLALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSE---L 145

  Fly    73 STGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQV--VISTVHKVSAEVKLSVRRPP 135
            :|                 .||.||..|..:|:.|||.|.|.|  .:..:.:..:||:::.....
Human   146 TT-----------------YSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSF 193

  Fly   136 VISDNSTQSVVASEGSEVQMECY-ASGYPTPTITWRRENNAILPTDS-ATYVGNTLRIKSVKKED 198
            :.:|   |....|:|....:... .:.||.|.:||.||.:.|:|::. |..:.|.|.|.:....|
Human   194 MDTD---QRKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSD 255

  Fly   199 RGTYYCVA---DNGVSKGD-------RRNINVEVEFAPVITVPRP--RLGQALQYDMDLECHIEA 251
            .|.||..|   .||.:|..       .|::......||.|.|| |  |...|...:..|||...|
Human   256 AGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVP-PGNRSVVAGSSETTLECIASA 319

  Fly   252 YPPP--AIVWTKDDIQLANNQH-----YSISHFATADEYTDSTLRVITVEKRQYGDYVCKAT--- 306
            .|..  ::.|.::.:::.:..|     .:||:..:||.                |.|||:|.   
Human   320 RPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADT----------------GPYVCEAALPG 368

  Fly   307 NRFGEAEARVNLF 319
            :.|..|.|...||
Human   369 SAFEPARATAFLF 381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 21/99 (21%)
FR1 37..50 CDD:409353 2/15 (13%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 0/6 (0%)
CDR1 51..59 CDD:409353 0/7 (0%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
FR2 60..63 CDD:409353 0/2 (0%)
CDR2 67..81 CDD:409353 3/13 (23%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 11/30 (37%)
Ig strand D 84..90 CDD:409353 0/5 (0%)
Ig strand E 94..102 CDD:409353 4/7 (57%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 0/7 (0%)
FR4 124..130 CDD:409353 2/5 (40%)
Ig strand G 124..130 CDD:409353 2/5 (40%)
Ig_3 134..208 CDD:404760 22/78 (28%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 2/3 (67%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 1/2 (50%)
Ig 227..318 CDD:416386 25/102 (25%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 0/3 (0%)
Ig strand F 300..305 CDD:409353 3/4 (75%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352 22/103 (21%)
Ig 122..176 CDD:143165 17/73 (23%)
Ig 219..265 CDD:299845 17/45 (38%)
IGc2 312..364 CDD:197706 15/67 (22%)
I-set 386..475 CDD:254352
Ig 404..472 CDD:143165
I-set 480..570 CDD:254352
Ig 494..570 CDD:299845
I-set 575..664 CDD:254352
Ig 580..664 CDD:299845
FN3 668..759 CDD:238020
fn3 771..857 CDD:278470
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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