DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and igcm-2

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_001362087.1 Gene:igcm-2 / 180913 WormBaseID:WBGene00020130 Length:802 Species:Caenorhabditis elegans


Alignment Length:314 Identity:86/314 - (27%)
Similarity:119/314 - (37%) Gaps:58/314 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 FVQQTLAQRTPTISYITQEQIKDIGGTVEFDCSVQ---YAKEYNVLFLKTDSDPVFLSTGSTLVI 80
            |.:.|:....|....:.:      |..|.:.|...   .|..|:.||.|..             |
 Worm   204 FTKATILDLIPLNKTVIE------GSNVFWHCHANAQATAISYSWLFEKKP-------------I 249

  Fly    81 KDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPP-VISDNSTQS 144
            |.:...||.:..|....||  |::::|:|.|||:...|.....|:...|.|..|| .:|.:....
 Worm   250 KTTSLGLRSNIRSGDLSLQ--DVRKSDSGWYTCEAKNSAGETTSSTAYLHVFYPPEPLSSHQPVQ 312

  Fly   145 VVASEGSEVQMECYASGYPTPT-ITWRRENNAILPTDSATYVGNTLRIKSVKKEDRGTYYCVADN 208
            .||| |....:.|.....|||| .||.: |...|||.:::::    .|...|..|.|.|.|.|||
 Worm   313 TVAS-GRNTTVSCDVIANPTPTSYTWSK-NGHYLPTQASSHI----IISYAKPGDGGIYGCQADN 371

  Fly   209 GVSKGDRRNINVEVEFAPVITVPRP-----RLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLAN 268
            ...||.....::.|...||.||..|     |||.    .:.:.|.....|.|.:.|.:|..::  
 Worm   372 IAGKGSIVETHLIVAEPPVFTVAPPSEIKVRLGD----QVSIPCQGFGDPMPIVYWIRDKKRI-- 430

  Fly   269 NQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFETI 322
            ||               |||....||...:|.|.|...|.......||.|...|
 Worm   431 NQ---------------STLTFKKVEHLDHGAYECVVANSVETISTRVMLLVEI 469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 24/97 (25%)
FR1 37..50 CDD:409353 2/12 (17%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 1/10 (10%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 0/13 (0%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 11/30 (37%)
Ig strand D 84..90 CDD:409353 2/5 (40%)
Ig strand E 94..102 CDD:409353 2/7 (29%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 1/7 (14%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 25/75 (33%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 2/4 (50%)
Ig strand E 187..191 CDD:409353 0/3 (0%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 25/95 (26%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 3/3 (100%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
igcm-2NP_001362087.1 IG_like 23..101 CDD:214653
Ig 124..200 CDD:386229
IG_like 214..298 CDD:214653 25/104 (24%)
Ig_3 309..371 CDD:372822 22/67 (33%)
Ig 389..467 CDD:386229 27/98 (28%)
FN3 476..548 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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