DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and Ncam2

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	412	Identity:	86/412 - (20%)
Similarity:	145/412 - (35%)	Gaps:	147/412 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 STLLLAIFVQQTLAQRTPTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGS 76
            :|::|.|:.:.|..:      .::.::.|. |...|..|.|..:....|.:|..:.:
Mouse   105 ATVVLEIYQKLTFRE------VVSPQEFKQ-GEDAEVVCRVSSSPAPAVSWLYHNEE-------- 154

  Fly    77 TLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVS-AEVKLSVRRPPVI--- 137
            ...|.|:||::..:.|     |||.:|.::|.|.|.|:..:....::. .::.:.|..||.|
Mouse   155 VTTIPDNRFAVLANNN-----LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAIMMP 214

  Fly   138 --SDNSTQSVVASEGSEVQMECYASGYPTPTITWRR------ENNA--------------ILPTD 180
              |.|:|    |..|.|:.:.|.|||.|.|||:|.|      ||..              |:..|
Mouse   215 QKSFNAT----AERGEEMTLTCKASGSPDPTISWFRNGKLIEENEKYILKGSNTELTVRNIINKD 275

  Fly   181 SATYV------------------------------------------------------------ 185
            ..:||
Mouse   276 GGSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNETTSENGHVTLVCEAEGEPVPEITWKRAIDG 340

  Fly   186 ---------------------GNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVEFAPVIT 229
                                 .::|.|:.||..|.|.|.|.|.:.:. |.:|::::::|:||...
Mouse   341 VMFSEGDKSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAASRIG-GHQRSMHLDIEYAPKFV 404

  Fly   230 VPRPRLGQALQYD-----MDLECHIEAYPPPAIVWTKDDIQL-ANNQHYSISHFATADEYTDSTL 288
                 ..|.:.|.     :::.|.:.|.||.:|.|.::.:.| |.|    .:|..|........|
Mouse   405 -----SNQTMYYSWEGNPINISCDVTANPPASIHWRREKLLLPAKN----TTHLKTHSVGRKMIL 460

  Fly   289 RVITVEKRQYGDYVCKATNRFG 310
            .:.......:|.|.|.||||.|
Mouse   461 EIAPTSDNDFGRYNCTATNRIG 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	20/95 (21%)
		FR1	37..50	CDD:409353	3/12 (25%)
		Ig strand A'	37..42	CDD:409353	1/4 (25%)
		Ig strand B	44..51	CDD:409353	1/6 (17%)
		CDR1	51..59	CDD:409353	1/7 (14%)
		Ig strand C	59..63	CDD:409353	1/3 (33%)
		FR2	60..63	CDD:409353	1/2 (50%)
		CDR2	67..81	CDD:409353	0/13 (0%)
		Ig strand C'	68..72	CDD:409353	0/3 (0%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	11/30 (37%)
		Ig strand D	84..90	CDD:409353	2/5 (40%)
		Ig strand E	94..102	CDD:409353	3/7 (43%)
		Ig strand F	108..115	CDD:409353	3/6 (50%)
		CDR3	116..124	CDD:409353	0/7 (0%)
		FR4	124..130	CDD:409353	0/6 (0%)
		Ig strand G	124..130	CDD:409353	0/6 (0%)
		Ig_3	134..208	CDD:404760	34/179 (19%)
		Ig strand B	153..157	CDD:409353	0/3 (0%)
		Ig strand C	166..170	CDD:409353	2/3 (67%)
		Ig strand E	187..191	CDD:409353	1/3 (33%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	1/2 (50%)
		Ig	227..318	CDD:416386	22/90 (24%)
		Ig strand C	256..260	CDD:409353	1/3 (33%)
		Ig strand E	286..290	CDD:409353	1/3 (33%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274	2/6 (33%)
		I-set	22..111	CDD:254352	2/5 (40%)
		I-set	117..193	CDD:254352	20/95 (21%)
		IGc2	128..189	CDD:197706	19/74 (26%)
		Ig	208..301	CDD:299845	25/96 (26%)
		I-set	215..298	CDD:254352	22/86 (26%)
		Ig	300..397	CDD:299845	11/97 (11%)
		IG_like	308..395	CDD:214653	11/87 (13%)
		IG_like	413..491	CDD:214653	20/74 (27%)
		IGc2	414..482	CDD:197706	19/71 (27%)
		FN3	496..588	CDD:238020
		fn3	594..678	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000