DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and rig-4

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_501339.2 Gene:rig-4 / 177597 WormBaseID:WBGene00004371 Length:2325 Species:Caenorhabditis elegans


Alignment Length:381 Identity:79/381 - (20%)
Similarity:136/381 - (35%) Gaps:118/381 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 QTLAQRTPTISYITQEQIKD--------IGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTL 78
            :|..|::..:::|::..:||        :|.::...|||:.....::.:.|           :.|
 Worm   309 RTSDQKSAYMTFISRPILKDLPNEIQKTVGSSLSLKCSVKKKSSMDIKWYK-----------NGL 362

  Fly    79 VIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVV------ISTV----------------- 120
            ::...|           .||.|..|::.|.|.|.|:..      :::|                 
 Worm   363 MMTTQR-----------GKLTIDRIKQDDFGLYQCEATNAAGADLASVWVKEGEANETVATEMSE 416

  Fly   121 HKVSAEVKLSVRRPP----VISDNSTQS-----------------------VVASEGSEVQMECY 158
            ..:|.|.::|:..||    ...|||...                       .|||....:.|||.
 Worm   417 DGMSLEEEISMETPPPRKLKFFDNSKSQEQLFPFTSELEPSQKLIKTPKDLTVASGTDRIMMECA 481

  Fly   159 ASGYPTPTITWRRENNAILPTDSATY--VGNTLRIKSVKKEDRGTYYC-VADNGVSKGDRRNINV 220
            |:|.|.|.|.|....:.| .||:..|  ..:.|.|..::|.|.|.|.| ::.:.|    :...||
 Worm   482 ATGSPPPNIIWLLNGHEI-QTDNVKYDLTNDGLAIHDIRKSDEGEYTCEISGSNV----KATANV 541

  Fly   221 EVEFAPVITVPRPRLGQALQYDMDLECHI--EAYPPPAIVWTKDDIQLANNQHYSISHFATADEY 283
            :|....:|..........:..:::..|.:  |.....::.|..:|:.|..|              
 Worm   542 QVNGDSLIEYGPADQKSLIGTNVEFSCEVAKEYVRKASVEWYLNDVLLPVN-------------- 592

  Fly   284 TDSTLRVITVEK-----RQY-----GDYVCKAT--NRFGEAEARVNLFETIIPVCP 327
            .:|.||:....|     ||.     |:|.|:.|  .|...|.|.:.:.|.  |..|
 Worm   593 GNSGLRISRNRKGSLIIRQVGPDNTGEYRCRVTVDGREENASAMLQIIEK--PAMP 646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 20/125 (16%)
FR1 37..50 CDD:409353 3/20 (15%)
Ig strand A' 37..42 CDD:409353 2/12 (17%)
Ig strand B 44..51 CDD:409353 0/6 (0%)
CDR1 51..59 CDD:409353 2/7 (29%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
FR2 60..63 CDD:409353 0/2 (0%)
CDR2 67..81 CDD:409353 1/13 (8%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 9/30 (30%)
Ig strand D 84..90 CDD:409353 1/5 (20%)
Ig strand E 94..102 CDD:409353 3/7 (43%)
Ig strand F 108..115 CDD:409353 3/6 (50%)
CDR3 116..124 CDD:409353 1/30 (3%)
FR4 124..130 CDD:409353 2/5 (40%)
Ig strand G 124..130 CDD:409353 2/5 (40%)
Ig_3 134..208 CDD:404760 28/103 (27%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 2/5 (40%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 20/104 (19%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 2/3 (67%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
rig-4NP_501339.2 IG_like 330..402 CDD:214653 16/93 (17%)
IGc2 338..393 CDD:197706 15/76 (20%)
I-set 459..543 CDD:254352 26/88 (30%)
IGc2 478..534 CDD:197706 20/56 (36%)
IG_like 553..639 CDD:214653 19/99 (19%)
Ig 564..635 CDD:143165 18/84 (21%)
FN3 643..747 CDD:238020 2/4 (50%)
FN3 756..850 CDD:238020
FN3 858..954 CDD:238020
FN3 959..1042 CDD:238020
FN3 1057..1151 CDD:238020
FN3 1156..1251 CDD:238020
FN3 1258..1356 CDD:238020
FN3 1361..1453 CDD:238020
FN3 1464..1560 CDD:238020
FN3 1572..1664 CDD:238020
FN3 1679..1764 CDD:238020
FN3 1774..1858 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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