DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and Hspg2

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_030109089.1 Gene:Hspg2 / 15530 MGIID:96257 Length:4398 Species:Mus musculus


Alignment Length:351 Identity:97/351 - (27%)
Similarity:147/351 - (41%) Gaps:77/351 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 WRPSISNCVWSTLLLA-IFVQQTLAQ---------RTPTISYITQEQIKDIGGTVEFDCSVQYAK 56
            :|..:||.|.|....| :.||.:.:.         .|||:....|.:.::||.:|||.|:|...:
Mouse  3374 YRCQVSNRVGSAEAFAQVLVQGSSSNLPDTSIPGGSTPTVQVTPQLETRNIGASVEFHCAVPNER 3438

  Fly    57 EYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVH 121
            ..::.:||....   |..|.:  ::|.             .|:|:::.::..|||.||     .|
Mouse  3439 GTHLRWLKEGGQ---LPPGHS--VQDG-------------VLRIQNLDQSCQGTYVCQ-----AH 3480

  Fly   122 ----KVSAEVKLSVRRPPVISDN---STQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPT 179
                :..|..:|.|:..|.:..|   |..|||.  |..|:.||.|.|.|.|.:||.:....:.| 
Mouse  3481 GPWGQAQATAQLIVQALPSVLINVRTSVHSVVV--GHSVEFECLALGDPKPQVTWSKVGGHLRP- 3542

  Fly   180 DSATYVGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVEFAPVITVP---RPRLGQALQY 241
             .....|:.:||..|:..|.|.|.|.|.|.... .:.::.:.|:..|.|:.|   |...|.|..:
Mouse  3543 -GIVQSGSIIRIAHVELADAGQYRCAATNAAGT-TQSHVLLLVQALPQISTPPEIRVPAGSAAVF 3605

  Fly   242 DMDLECHIEAYPPPAIVWTK------DDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGD 300
                .|....||.|||.|:|      .|.:|.||.                 |.:.:|.....|.
Mouse  3606 ----PCMASGYPTPAITWSKVDGDLPPDSRLENNM-----------------LMLPSVRPEDAGT 3649

  Fly   301 YVCKATNRFG--EAEARVNLFETIIP 324
            |||.||||.|  :|.|.:.:.|.:||
Mouse  3650 YVCTATNRQGKVKAFAYLQVPERVIP 3675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 23/98 (23%)
FR1 37..50 CDD:409353 5/12 (42%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 3/6 (50%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
FR2 60..63 CDD:409353 0/2 (0%)
CDR2 67..81 CDD:409353 2/13 (15%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 6/30 (20%)
Ig strand D 84..90 CDD:409353 0/5 (0%)
Ig strand E 94..102 CDD:409353 2/7 (29%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 1/11 (9%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 26/76 (34%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 0/3 (0%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 30/101 (30%)
Ig strand C 256..260 CDD:409353 2/3 (67%)
Ig strand E 286..290 CDD:409353 1/3 (33%)
Ig strand F 300..305 CDD:409353 3/4 (75%)
Hspg2XP_030109089.1 EGF_CA 4153..4184 CDD:238011
LamG 4211..4369 CDD:238058
SEA 80..194 CDD:382994
LDLa 216..251 CDD:238060
Ldl_recept_a 300..336 CDD:365841
LDLa 342..376 CDD:238060
LDLa 385..420 CDD:238060
Ig_Perlecan_like 438..515 CDD:143220
LamB 607..733 CDD:214597
EGF_Lam 781..823 CDD:238012
EGF_Lam 830..887 CDD:238012
Laminin_EGF 896..938 CDD:365839
Laminin_B 1007..1141 CDD:365838
EGF_Lam 1175..1224 CDD:238012
EGF_Lam 1225..1281 CDD:238012
Laminin_EGF 1292..1339 CDD:365839
Laminin_B 1413..1545 CDD:365838
EGF_Lam 1580..1628 CDD:238012
EGF_Lam 1629..1686 CDD:238012
IG_like 1699..1779 CDD:214653
Ig_Perlecan_like 1787..1872 CDD:143231
IG_like 1888..1966 CDD:214653
I-set 1972..2058 CDD:369462
IG_like 2073..2150 CDD:214653
IG 2174..2249 CDD:214652
IG 2269..2342 CDD:214652
IG 2364..2441 CDD:214652
Ig 2450..2535 CDD:386229
IG 2563..2632 CDD:214652
IGc2 2658..2717 CDD:197706
IG_like 2748..2825 CDD:214653
IG 2846..2922 CDD:214652
IG_like 2943..3021 CDD:214653
Ig 3034..3120 CDD:386229
IG_like 3132..3213 CDD:214653
IG 3230..3306 CDD:214652
Ig 3327..3390 CDD:319273 5/15 (33%)
Ig 3428..3494 CDD:386229 20/88 (23%)
Ig 3518..3583 CDD:386229 19/67 (28%)
I-set 3587..3669 CDD:369462 31/102 (30%)
LamG 3676..3833 CDD:238058 97/351 (28%)
EGF_CA 3856..3889 CDD:238011
EGF_CA <3901..3930 CDD:238011
LamG 3942..4091 CDD:238058
EGF 4116..4146 CDD:333761
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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