DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and IGSF5

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_011527774.1 Gene:IGSF5 / 150084 HGNCID:5952 Length:497 Species:Homo sapiens


Alignment Length:219 Identity:53/219 - (24%)
Similarity:93/219 - (42%) Gaps:32/219 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 GGTVEFDCSVQYAKEYNVLFLKTDSDPVFLST-GSTLVIKDSRF-SLRYDPNSS-TYKLQIKDIQ 104
            |....|:|:|....:   |.:...||.|.||. ....:|.:.|| |.|||...: |.::.|.:::
Human   143 GSQARFNCTVSQGWK---LIMWALSDMVVLSVRPMEPIITNDRFTSQRYDQGGNFTSEMIIHNVE 204

  Fly   105 ETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQMECYASGYP-TPTIT 168
            .:|:|...|.:..|.:|. ||.:.:.|.....|   .:.::|.:|....::.|..|.:. .|.|:
Human   205 PSDSGNIRCSLQNSRLHG-SAYLTVQV
MGELFI---PSVNLVVAENEPCEVTCLPSHWTRLPDIS 265

  Fly   169 WRRENNAILPTDSATY-------VGNTLRIKSVKKEDRGTYYCVAD-NGVSKGDRRNINVEVEFA 225
            |..   .:|.:.|:.|       :.:.:.|.::..:..||..|||. ..:.......:|:.|...
Human   266 WEL---GLLVSHSSYYFVPEPSDLQSAVSILALTPQSNGTLTCVATWKSLKARKSATVNLTVIRC 327

  Fly   226 PV-----ITVP-----RPRLGQAL 239
            |.     |.:|     .|.||.:|
Human   328 PQDTGGGINIPGVLSSLPSLGFSL 351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 26/90 (29%)
FR1 37..50 CDD:409353 2/6 (33%)
Ig strand A' 37..42 CDD:409353
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 5/14 (36%)
Ig strand C' 68..72 CDD:409353 2/3 (67%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 11/32 (34%)
Ig strand D 84..90 CDD:409353 4/6 (67%)
Ig strand E 94..102 CDD:409353 2/8 (25%)
Ig strand F 108..115 CDD:409353 2/6 (33%)
CDR3 116..124 CDD:409353 2/7 (29%)
FR4 124..130 CDD:409353 2/5 (40%)
Ig strand G 124..130 CDD:409353 2/5 (40%)
Ig_3 134..208 CDD:404760 17/82 (21%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 0/3 (0%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 6/23 (26%)
Ig strand C 256..260 CDD:409353
Ig strand E 286..290 CDD:409353
Ig strand F 300..305 CDD:409353
IGSF5XP_011527774.1 IG_like 135..228 CDD:214653 26/88 (30%)
Ig <200..230 CDD:299845 8/30 (27%)
Ig 236..307 CDD:299845 15/76 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143418
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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