DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lac and AgaP_AGAP011194

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_309450.4 Gene:AgaP_AGAP011194 / 1270731 VectorBaseID:AGAP011194 Length:470 Species:Anopheles gambiae


Alignment Length:313 Identity:89/313 - (28%)
Similarity:138/313 - (44%) Gaps:51/313 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 VQQTLAQRTPTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVI-KDS 83
            ||.....|:.::..:       ||.|:...|.|:.... |:|..:..|..|   |.:.|:| :|:
Mosquito    30 VQPKFTSRSQSVRAV-------IGDTITLPCEVENLGR-NILLWRRGSAVV---TAANLIITRDT 83

  Fly    84 RFSLRYDPNSSTYKLQIKDIQETDAGTYTCQV----VISTVHKVSAEVKLSVRRPPVISDNSTQS 144
            ||.|     ...|.||||:::..|||.|.||:    ....||.|...|..|||..|     .|..
Mosquito    84 RFKL-----LEGYSLQIKNVRPQDAGDYNCQIGDHDNRDLVHTVEILVPPSVRSNP-----ETGH 138

  Fly   145 VVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSATYVGNTLRIKSVKKEDRGTYYCVADNG 209
            |...:|....:||.|||.|.|:|:|.|:::  :........|.||.:::|.::|.|||.|.||||
Mosquito   139 VTVRKGGTATLECKASGNPVPSISWTRKDS--IHGSPHLSEGPTLTLENVNRQDSGTYRCYADNG 201

  Fly   210 VSKGDRRNINVEVEF----APVITVPRPRLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQ 270
            :    |..:.|:::.    .|.|||.:..:.....|:..|.|.:.....|.::|.:|...|..|.
Mosquito   202 I----REPVFVDMQLIVLSPPEITVEKSWVHAGEGYEAQLVCTVHGDANPEVMWYQDSFLLHPND 262

  Fly   271 HYSI-----SHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAEARVNL 318
            ..::     .|:.|          |..|....:|:|.|.|.|..|.|:..:.:
Mosquito   263 RRTMDTRGEKHYLT----------VRNVRASDFGNYSCVAENSLGRAKKYIEV 305

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 31/99 (31%)
FR1 37..50 CDD:409353 3/12 (25%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 2/3 (67%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 5/14 (36%)
Ig strand C' 68..72 CDD:409353 1/3 (33%)
Ig strand C' 79..81 CDD:409353 1/2 (50%)
FR3 84..115 CDD:409353 13/30 (43%)
Ig strand D 84..90 CDD:409353 3/5 (60%)
Ig strand E 94..102 CDD:409353 4/7 (57%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 2/7 (29%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 24/73 (33%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 2/3 (67%)
Ig strand F 201..206 CDD:409353 3/4 (75%)
Ig strand G 215..218 CDD:409353 1/2 (50%)
Ig 227..318 CDD:416386 22/95 (23%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 0/3 (0%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
AgaP_AGAP011194XP_309450.4 IG_like 38..126 CDD:214653 30/103 (29%)
Ig 49..110 CDD:143165 23/69 (33%)
IG_like 137..214 CDD:214653 27/82 (33%)
IGc2 144..200 CDD:197706 21/57 (37%)
I-set 218..305 CDD:254352 23/96 (24%)
Ig 235..304 CDD:143165 18/78 (23%)
FN3 <357..415 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X97
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.