DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and Dscaml1

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:NP_001074739.2 Gene:Dscaml1 / 114873 MGIID:2150309 Length:2053 Species:Mus musculus


Alignment Length:307 Identity:83/307 - (27%)
Similarity:127/307 - (41%) Gaps:39/307 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 AQRTPTISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRY 89
            |:..|||......|....|.:||..|:   |..|.:..::      :|..|..|. .|||::.|.
Mouse   222 AESIPTILDGFHSQEVWTGHSVELPCA---ASGYPIPAIR------WLKDGRPLP-ADSRWAKRI 276

  Fly    90 DPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQ 154
            .      .|.|.|::..|:|||.|:|. :|.....|...|:|..|..:: .:.:.:....||.|.
Mouse   277 T------GLTISDLRTEDSGTYICEVT-NTFGSAEANGILTVIDPLHVT-LTPKKLKTGIGSTVI 333

  Fly   155 MECYASGYPTPTITWRRENNAILPTDSATYVG---NTLRIKSVKKEDRGTYYCVADNGVSKGDRR 216
            :.|..:|.|..||.|.|....:||.::.:..|   .||.|.|.:|...|.|.|.|        .|
Mouse   334 LSCALTGSPEFTIRWYRNTELVLPGEAISIRGLSNETLLISSAQKSHSGAYQCFA--------TR 390

  Fly   217 NINVEVEFAPVITVP-RPRLGQALQ-------YDMDLECHIEAYPPPAIVWTKDDIQLANNQHYS 273
            ......:||.::... .||:..:..       ....|.|..:..|||.:.|..||..:..:..:.
Mouse   391 KAQTAQDFAIIVLEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHR 455

  Fly   274 ISHFATADEYTDSTLRVITVEKRQYGDYVCKATNRFGEAE--ARVNL 318
            .:.:..:|..|.|.:.|...:.|..|.|.|.|.|..|.||  ||:|:
Mouse   456 TNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNSVGSAEYQARINV 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 26/94 (28%)
FR1 37..50 CDD:409353 4/12 (33%)
Ig strand A' 37..42 CDD:409353 1/4 (25%)
Ig strand B 44..51 CDD:409353 2/6 (33%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 0/3 (0%)
FR2 60..63 CDD:409353 0/2 (0%)
CDR2 67..81 CDD:409353 3/13 (23%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 10/30 (33%)
Ig strand D 84..90 CDD:409353 2/5 (40%)
Ig strand E 94..102 CDD:409353 2/7 (29%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 1/7 (14%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 23/76 (30%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 2/3 (67%)
Ig strand E 187..191 CDD:409353 2/3 (67%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 1/2 (50%)
Ig 227..318 CDD:416386 25/100 (25%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 1/3 (33%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
Dscaml1NP_001074739.2 IGc2 43..110 CDD:197706
Ig 125..218 CDD:353325
I-set 226..311 CDD:336764 29/101 (29%)
Ig_3 317..389 CDD:339005 22/80 (28%)
Ig 408..498 CDD:353325 23/89 (26%)
IGc2 519..577 CDD:197706
Ig 615..681 CDD:319273
Ig_DSCAM 707..785 CDD:143211
Ig 803..891 CDD:353325
FN3 887..981 CDD:238020
FN3 988..1085 CDD:238020
FN3 1093..1186 CDD:238020
FN3 1191..1282 CDD:238020
Ig 1307..1377 CDD:319273
FN3 1384..1474 CDD:238020
FN3 1488..1560 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1716..1741
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1773..1803
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1840..1862
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1974..2053
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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