DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and ncam2

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_571905.1	Gene:	ncam2 / 114441	ZFINID:	ZDB-GENE-010822-1	Length:	795	Species:	Danio rerio

Alignment Length:	350	Identity:	80/350 - (22%)
Similarity:	140/350 - (40%)	Gaps:	63/350 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LAQRTPTISYITQEQIK---DIGGTVEFDCSVQYAKEYNVLF------LKTDSDPVFLSTGSTLV 79
            |....|.:..:.|:...   |.|.:|.|.|....:.|.:|.:      |:.....|..:.|:||.
Zfish   201 LVVNVPPVVSVPQQSFNATADYGESVTFTCRAYGSPEPDVTWHRKGVQLQESERYVMRARGTTLT 265

  Fly    80 IKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQS 144
                                :::||:.|.|:|||: ..:...:|..|:.|.|...|.|:  ..::
Zfish   266 --------------------VRNIQQDDGGSYTCR-ASNKAGEVEHELFLKVFVQPHIT--KLRN 307

  Fly   145 VVASEGSEVQMECYASGYPTPTITWRRENNAILPTDS-----------ATYVGNTLRIKSVKKED 198
            |.|.|||...:.|.|.|.|.|.|:|||.::....:|.           ..|..:.|.|..||..|
Zfish   308 VTAVEGSAAMISCKAEGEPLPEISWRRASDGHSFSDGDKSPDGRVEVRGRYGESMLTIVVVKLSD 372

  Fly   199 RGTYYCVADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQYDMDLECHIEAYPPPAIVWTKDD 263
            .|.:.|.|.:.:. |.::::.:::|:||................:::.|.:.:.||..::|.::.
Zfish   373 WGRFDCEALSRIG-GHQKSMFLDIEYAPKFQANHTIFFSWEGNPVNISCDVMSNPPATMLWRREK 436

  Fly   264 IQL----ANNQHYSISHFATADEYT---DSTLRVITVEKRQYGDYVCKATNRFGEAEARVNLFET 321
            :.:    |.|...          ||   .|.|.|..:..|.:|.|.|.|.|..|.......|.:.
Zfish   437 LTIPSEGAGNMRV----------YTAPGRSLLEVTPMSDRDFGRYNCTARNNIGMRFQEFILAQA 491

  Fly   322 IIPVCPPACGQAYIAGAEDVSATSF 346
            .:|..|.:...:.:  |:.|:..:|
Zfish   492 DVPSNPYSVRLSSV--AQRVATVTF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	23/103 (22%)
		FR1	37..50	CDD:409353	4/15 (27%)
		Ig strand A'	37..42	CDD:409353	0/7 (0%)
		Ig strand B	44..51	CDD:409353	2/6 (33%)
		CDR1	51..59	CDD:409353	1/7 (14%)
		Ig strand C	59..63	CDD:409353	1/9 (11%)
		FR2	60..63	CDD:409353	1/8 (13%)
		CDR2	67..81	CDD:409353	4/13 (31%)
		Ig strand C'	68..72	CDD:409353	1/3 (33%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	7/30 (23%)
		Ig strand D	84..90	CDD:409353	0/5 (0%)
		Ig strand E	94..102	CDD:409353	0/7 (0%)
		Ig strand F	108..115	CDD:409353	4/6 (67%)
		CDR3	116..124	CDD:409353	0/7 (0%)
		FR4	124..130	CDD:409353	1/5 (20%)
		Ig strand G	124..130	CDD:409353	1/5 (20%)
		Ig_3	134..208	CDD:404760	26/84 (31%)
		Ig strand B	153..157	CDD:409353	0/3 (0%)
		Ig strand C	166..170	CDD:409353	1/3 (33%)
		Ig strand E	187..191	CDD:409353	1/3 (33%)
		Ig strand F	201..206	CDD:409353	1/4 (25%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	18/97 (19%)
		Ig strand C	256..260	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	2/3 (67%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
ncam2	NP_571905.1	Ig1_NCAM-2	20..111	CDD:143274
		I-set	21..110	CDD:254352
		IGc2	127..187	CDD:197706
		Ig	213..299	CDD:299845	24/106 (23%)
		I-set	213..296	CDD:254352	23/103 (22%)
		Ig	298..395	CDD:299845	27/99 (27%)
		I-set	300..393	CDD:254352	27/95 (28%)
		IG_like	411..488	CDD:214653	18/86 (21%)
		IGc2	412..480	CDD:197706	17/77 (22%)
		FN3	494..586	CDD:238020	4/22 (18%)
		fn3	<616..675	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100