Protein Alignment Lac and CHL1

DIOPT Version :9

• Sequence 1: NP_523713.2
• Gene: Lac / 36363
• FlyBaseID: FBgn0010238
• Length: 359
• Species: Drosophila melanogaster
• Sequence 2: NP_006605.2
• Gene: CHL1 / 10752
• HGNCID: 1939
• Length: 1224
• Species: Homo sapiens
• Alignment Length: 229
• Identity: 57/229 - (24%)
• Similarity: 92/229 - (40%)
• Gaps: 22/229 - (9%)

  Fly    98 LQIKDIQETDAGTYTCQVVISTVHKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQMECYASGY 162
            |:|:::...|.|.|.| ...:.:...:.:..:.|..||..: ...||.|.|.||...:.|.|.|.
Human   311 LKIENVSYQDKGNYRC-TASNFLGTATHDFHVIVEEPPRWT-KKPQSAVYSTGSNGILLCEAEGE 373

  Fly   163 PTPTITWRRENNAILPTDSATYVGNT-----LRIKSVKKEDRGTYYCVADNGVSKGDRRNINVE- 221
            |.|||.||...:   |.|:..:.|:.     :...:::......|.|.|.| |......|.|::
Human   374 PQPTIKWRVNGS---PVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASN-VHGTILANANIDV 434

  Fly   222 VEFAPVI-TVPRPRLGQALQYDMDLECHIEAYPPPAIVWTK-DDIQLANNQHYSISHFATADEYT 284
            |:..|:| |.........:.|...|.|...|.|...:.|.| ::::....:.|.|        |.
Human   435 VDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHI--------YE 491

  Fly   285 DSTLRVITVEKRQYGDYVCKATNRFGEAEARVNL 318
            :.||::....:...|.|.|...|..|:.....||
Human   492 NGTLQINRTTEEDAGSYSCWVENAIGKTAVTANL 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	6/32 (19%)
		FR1	37..50	CDD:409353
		Ig strand A'	37..42	CDD:409353
		Ig strand B	44..51	CDD:409353
		CDR1	51..59	CDD:409353
		Ig strand C	59..63	CDD:409353
		FR2	60..63	CDD:409353
		CDR2	67..81	CDD:409353
		Ig strand C'	68..72	CDD:409353
		Ig strand C'	79..81	CDD:409353
		FR3	84..115	CDD:409353	6/16 (38%)
		Ig strand D	84..90	CDD:409353
		Ig strand E	94..102	CDD:409353	2/3 (67%)
		Ig strand F	108..115	CDD:409353	3/6 (50%)
		CDR3	116..124	CDD:409353	0/7 (0%)
		FR4	124..130	CDD:409353	0/5 (0%)
		Ig strand G	124..130	CDD:409353	0/5 (0%)
		Ig_3	134..208	CDD:404760	23/78 (29%)
		Ig strand B	153..157	CDD:409353	0/3 (0%)
		Ig strand C	166..170	CDD:409353	2/3 (67%)
		Ig strand E	187..191	CDD:409353	0/8 (0%)
		Ig strand F	201..206	CDD:409353	2/4 (50%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	19/92 (21%)
		Ig strand C	256..260	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	2/3 (67%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
CHL1	NP_006605.2	Ig	55..126	CDD:299845
		Ig2_L1-CAM_like	129..223	CDD:143253
		IG_like	140..224	CDD:214653
		IG_like	264..343	CDD:214653	6/32 (19%)
		Ig3_L1-CAM_like	274..344	CDD:143208	6/33 (18%)
		IG_like	353..434	CDD:214653	25/84 (30%)
		Ig4_L1-NrCAM_like	361..435	CDD:143179	21/77 (27%)
		IG_like	447..525	CDD:214653	17/85 (20%)
		Ig	457..525	CDD:299845	16/75 (21%)
		IG_like	548..624	CDD:214653
		Ig	548..616	CDD:143165
		DGEA	571..574
		FN3	628..717	CDD:238020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	709..732
		fn3	731..811	CDD:278470
		FN3	834..927	CDD:238020
		FN3	932..1027	CDD:238020
		Bravo_FIGEY	1120..1205	CDD:290593
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1147..1179
		FIG[AQ]Y	1197..1201
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1205..1224

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10455
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100